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Literature summary extracted from

  • Guimaraes, M.J.; Bazan, J.F.; Castagnola, J.; Diaz, S.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Varki, A.; Zlotnik, A.
    Molecular cloning and characterization of lysosomal sialic acid O-acetylesterase (1996), J. Biol. Chem., 271, 13697-13705.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.53 expressed in COS-7 cells, both the larger and smaller Lse subunit Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.53 Diethyl-4-nitrophenylphosphate
-
 Mus musculus
3.1.1.53 Diethyl-4-nitrophenylphosphate
-
 Rattus norvegicus
3.1.1.53 diisopropyl fluorophosphate
-
 Mus musculus
3.1.1.53 diisopropyl fluorophosphate
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.53 75000
-
 x * 75000, nonreducing SDS-PAGE Mus musculus
3.1.1.53 250000
-
 nonreducing PAGE, equal MW for both the larger and smaller Lse subunit, expressed in COS-7 cells Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.53 Mus musculus P70665
-
-
3.1.1.53 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.53 side-chain modification
-
 Rattus norvegicus
3.1.1.53 side-chain modification glycoprotein, Lse Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.53 FDCP-Mix cl.A4 cell hepatoietic cell line Mus musculus
-
3.1.1.53 liver
-
 Rattus norvegicus
-
3.1.1.53 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.53 N-acetyl-9-O-acetylneuraminate + H2O
-
 Rattus norvegicus N-acetylneuraminate + acetate
-
 ?
3.1.1.53 N-acetyl-9-O-acetylneuraminate + H2O
-
 Mus musculus N-acetylneuraminate + acetate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.53 ?
-
 Rattus norvegicus
3.1.1.53 ? x * 75000, nonreducing SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.1.1.53 Lse
-
 Rattus norvegicus
3.1.1.53 Lse
-
 Mus musculus
3.1.1.53 lysosomal sialic acid O-acetylesterase
-
 Rattus norvegicus
3.1.1.53 lysosomal sialic acid O-acetylesterase
-
 Mus musculus