BRENDA - Enzyme Database

Characterization of heparin low-affinity phospholipase A1 present in brain and testicular tissue

Uchiyama, S.I.; Miyazaki, Y.; Amakasu, Y.; Kuwata, H.; Nakatani, Y.; Atsumi, G.I.; Murakami, M.; Kudo, I.; J. Biochem. 125, 1001-1010 (1999)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.1.32
gentamycin
the inhibition by aminoglycosides appears to be due to substrate depletion caused by binding of aminoglycosides to the negatively charged phospholipid and can be overcome by raising the substrate concentration
Rattus norvegicus
3.1.1.32
tobramycin
the inhibition by aminoglycosides appears to be due to substrate depletion caused by binding of aminoglycosides to the negatively charged phospholipid and can be overcome by raising the substrate concentration
Rattus norvegicus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.1.32
Ca2+
independent of Ca2+ at pHs below 7.4, striking pH dependence at alkaline pH
Bos taurus
3.1.1.32
Ca2+
independent of Ca2+ at pHs below 7.4, striking pH dependence at alkaline pH
Mus musculus
3.1.1.32
Ca2+
independent of Ca2+ at pHs below 7.4, striking pH dependence at alkaline pH
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.1.32
Bos taurus
-
-
-
3.1.1.32
Mus musculus
-
-
-
3.1.1.32
Rattus norvegicus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
3.1.1.32
-
Bos taurus
3.1.1.32
-
Mus musculus
3.1.1.32
-
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.32
brain
-
Bos taurus
-
3.1.1.32
brain
-
Mus musculus
-
3.1.1.32
brain
-
Rattus norvegicus
-
3.1.1.32
testis
-
Bos taurus
-
3.1.1.32
testis
-
Mus musculus
-
3.1.1.32
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.32
additional information
the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity
94340
Mus musculus
?
-
-
-
-
3.1.1.32
additional information
the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity
94340
Rattus norvegicus
?
-
-
-
-
3.1.1.32
additional information
the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity
94340
Bos taurus
?
-
-
-
-
3.1.1.32
phosphatidylethanolamine + H2O
-
94340
Mus musculus
?
-
-
-
?
3.1.1.32
phosphatidylethanolamine + H2O
-
94340
Rattus norvegicus
?
-
-
-
?
3.1.1.32
phosphatidylethanolamine + H2O
-
94340
Bos taurus
?
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.1.32
gentamycin
the inhibition by aminoglycosides appears to be due to substrate depletion caused by binding of aminoglycosides to the negatively charged phospholipid and can be overcome by raising the substrate concentration
Rattus norvegicus
3.1.1.32
tobramycin
the inhibition by aminoglycosides appears to be due to substrate depletion caused by binding of aminoglycosides to the negatively charged phospholipid and can be overcome by raising the substrate concentration
Rattus norvegicus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.1.32
Ca2+
independent of Ca2+ at pHs below 7.4, striking pH dependence at alkaline pH
Bos taurus
3.1.1.32
Ca2+
independent of Ca2+ at pHs below 7.4, striking pH dependence at alkaline pH
Mus musculus
3.1.1.32
Ca2+
independent of Ca2+ at pHs below 7.4, striking pH dependence at alkaline pH
Rattus norvegicus
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.1.32
-
Bos taurus
3.1.1.32
-
Mus musculus
3.1.1.32
-
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.32
brain
-
Bos taurus
-
3.1.1.32
brain
-
Mus musculus
-
3.1.1.32
brain
-
Rattus norvegicus
-
3.1.1.32
testis
-
Bos taurus
-
3.1.1.32
testis
-
Mus musculus
-
3.1.1.32
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.32
additional information
the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity
94340
Mus musculus
?
-
-
-
-
3.1.1.32
additional information
the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity
94340
Rattus norvegicus
?
-
-
-
-
3.1.1.32
additional information
the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity
94340
Bos taurus
?
-
-
-
-
3.1.1.32
phosphatidylethanolamine + H2O
-
94340
Mus musculus
?
-
-
-
?
3.1.1.32
phosphatidylethanolamine + H2O
-
94340
Rattus norvegicus
?
-
-
-
?
3.1.1.32
phosphatidylethanolamine + H2O
-
94340
Bos taurus
?
-
-
-
?