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Literature summary extracted from

  • Fishbein, W.N.; Bessman, S.P.
    Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. I. Tissue localization, stoichiometry, specificity, distinction from esterase (1966), J. Biol. Chem., 241, 4835-4841.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.1.1.25 freezing destroys 30-50% of the activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.25 EDTA
-
 Homo sapiens
3.1.1.25 EDTA
-
 Rattus norvegicus
3.1.1.25 eserine weak inhibition Rattus norvegicus
3.1.1.25 ethanol 6%, 85% inhibition Rattus norvegicus
3.1.1.25 ethyl beta-hydroxybutyrate weak inhibition Rattus norvegicus
3.1.1.25 neostigmine
-
 Rattus norvegicus
3.1.1.25 PCMB 0.1 mM Homo sapiens
3.1.1.25 PCMB 0.1 mM Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.25 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.25 Homo sapiens
-
-
-
3.1.1.25 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.25
-
 Homo sapiens
3.1.1.25
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.25 blood plasma
-
 Homo sapiens
-
3.1.1.25 blood plasma
-
 Rattus norvegicus
-
3.1.1.25 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.25 gamma-butyrolactone + H2O
-
 Homo sapiens gamma-hydroxybutyrate
-
 r
3.1.1.25 gamma-butyrolactone + H2O
-
 Rattus norvegicus gamma-hydroxybutyrate
-
 r
3.1.1.25 gamma-caprolactone + H2O
-
 Homo sapiens gamma-hydroxycaproate
-
 r
3.1.1.25 gamma-caprolactone + H2O
-
 Rattus norvegicus gamma-hydroxycaproate
-
 r
3.1.1.25 gamma-octalactone + H2O
-
 Homo sapiens 4-hydroxyoctanoate
-
 r
3.1.1.25 gamma-octalactone + H2O
-
 Rattus norvegicus 4-hydroxyoctanoate
-
 r
3.1.1.25 gamma-valerolactone + H2O
-
 Homo sapiens gamma-hydroxyvalerate
-
 r
3.1.1.25 gamma-valerolactone + H2O
-
 Rattus norvegicus gamma-hydroxyvalerate
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.25 32
-
-
 Homo sapiens
3.1.1.25 32
-
-
 Rattus norvegicus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.1.1.25 15 37 15°C: about 65% of maximal activity, 37°C: about 90% of maximal activity Homo sapiens
3.1.1.25 15 37 15°C: about 65% of maximal activity, 37°C: about 90% of maximal activity Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.1.25 90
-
 4 min, complete loss of activity Homo sapiens
3.1.1.25 90
-
 4 min, complete loss of activity Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.25 6
-
 lactonization Homo sapiens
3.1.1.25 6
-
 lactonization Rattus norvegicus
3.1.1.25 8.6
-
 hydrolysis Homo sapiens
3.1.1.25 8.6
-
 hydrolysis Rattus norvegicus