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Literature summary extracted from

  • Tada, Mi.; Tada, Ma.
    Seryl-tRNA synthetase and activation of the carcinogen 4-nitroquinoline 1-oxide (1975), Nature, 255, 510-512.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.11 additional information Saccharomyces cerevisiae catalyzes the binding of 4-hydroxyaminoquinoline 1-oxide (a reduced metabolite of the carcinogenic and mutagenic compound 4-nitroquinoline 1-oxide) to nucleic acid. Seryl-tRNA synthetase may participate in vivo in the activation of some N-hydroxy compounds through their aminoacylation capacity ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.11 Rattus norvegicus
-
-
-
6.1.1.11 Saccharomyces cerevisiae
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-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.1.1.11
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.11 ATP + L-serine + tRNASer
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 Rattus norvegicus AMP + diphosphate + L-seryl-tRNASer
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 ?
6.1.1.11 ATP + L-serine + tRNASer
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 Saccharomyces cerevisiae AMP + diphosphate + L-seryl-tRNASer
-
 ?
6.1.1.11 additional information catalyzes the binding of 4-hydroxyaminoquinoline 1-oxide (a reduced metabolite of the carcinogenic and mutagenic compound 4-nitroquinoline 1-oxide) to nucleic acid. Seryl-tRNA synthetase may participate in vivo in the activation of some N-hydroxy compounds through their aminoacylation capacity Saccharomyces cerevisiae ?
-
 ?