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Literature summary extracted from

  • Giovanelli, J.
    Oxalyl-coenzyme A synthetase from pea seed (1966), Biochim. Biophys. Acta, 118, 124-143.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.8 hydroxylamine inhibition of ATP-diphosphate exchange Pisum sativum
6.2.1.8 MgCl2 high concentrations cause a marked inhibition of ATP-diphosphate exchange Pisum sativum
6.2.1.8 NaF slight inhibition of ATP-diphosphate exchange Pisum sativum
6.2.1.8 oxalate high concentrations cause a slight inhibition of ATP-diphosphate exchange Pisum sativum
6.2.1.8 PCMB inhibition of ATP-diphosphate exchange. Reversal of inhibition by GSH or cysteine Pisum sativum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.8 0.1
-
CoA
-
Pisum sativum
6.2.1.8 2
-
oxalate
-
Pisum sativum
6.2.1.8 4
-
ATP
-
Pisum sativum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.8 Mg2+ required Pisum sativum

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.8 Lupinus sp.
-
-
-
6.2.1.8 Pisum sativum
-
L. var. Telephone
-
6.2.1.8 Pumpkin
-
-
-
6.2.1.8 Triticum aestivum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.8 seed
-
Lupinus sp.
-
6.2.1.8 seed
-
Triticum aestivum
-
6.2.1.8 seed
-
Pisum sativum
-
6.2.1.8 seed
-
Pumpkin
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.8 ATP + oxalate + CoA highly specific for oxalate Pisum sativum AMP + diphosphate + oxalyl-CoA
-
?
6.2.1.8 CTP + oxalate + CoA at 15% the activity relative to ATP Pisum sativum CMP + diphosphate + oxalyl-CoA
-
?
6.2.1.8 GTP + oxalate + CoA at 6% of the activity relative to ATP Pisum sativum GMP + diphosphate + oxalyl-CoA
-
?
6.2.1.8 additional information enzyme catalyzes oxalate-dependent and CoA-independent ATP-diphosphate exchange Pisum sativum ?
-
?
6.2.1.8 UTP + oxalate + CoA at 21% the activity relative to ATP Pisum sativum UMP + diphosphate + oxalyl-CoA
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.8 7.4
-
ATP-diphosphate exchange Pisum sativum

pH Range

EC Number pH Minimum pH Maximum Comment Organism
6.2.1.8 6.3 8.6 6.3: about 60% of maximal activity, 8.6: about 50% of maximal activity, ATP-diphosphate exchange Pisum sativum