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Literature summary extracted from

  • Vessey, D.A.; Zakim, D.
    Characterization of microsomal choloyl-coenzyme A synthetase (1977), Biochem. J., 163, 357-362.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.7 ATP inhibition above 3 mM Cavia porcellus
6.2.1.7 Bile acids conjugated bile acids are less efficient inhibitors than unconjugated bile acids, deoxycholate is the most potent Cavia porcellus
6.2.1.7 deoxycholate
-
 Cavia porcellus
6.2.1.7 fatty acids inhibition is not important in vivo owing to the high concentrations required for inhibition Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.7 0.006
-
 cholate
-
 Cavia porcellus
6.2.1.7 0.05
-
 cholate CoA Cavia porcellus
6.2.1.7 0.65
-
 ATP
-
 Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.7 microsome membrane Cavia porcellus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.7 Ca2+ modest enhancement of activity Cavia porcellus
6.2.1.7 Fe2+ modest enhancement of activity Cavia porcellus
6.2.1.7 Mg2+ divalent cation required, Mn2+ or Mg2+ most effective Cavia porcellus
6.2.1.7 Mn2+ divalent cation required, Mn2+ or Mg2+ are most effective Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.7 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.7 liver
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.7 ATP + cholate + CoA
-
 Cavia porcellus AMP + diphosphate + choloyl-CoA
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.7 7.2 7.3
-
 Cavia porcellus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
6.2.1.7 6 8 6.0: about 40% of maximal activity, 8.0: about 50% of maximal activity Cavia porcellus