EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
6.2.1.5 | N142N | mutant H142N is devoid of the ability to catalyze the overall reaction but is able to catalyze the half-reactions at significant rates. Phosphorylation by ATP and dephosphorylation by ADP of the mutant enzyme occurs at rates that are at least 10times greater than those with wild type enzyme. Dephosphorylation by succinate plus CoA, succinyl-CoA formation, proceeds with a maximal velocity of 10% that of wild type enzyme | Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
6.2.1.5 | ADP | adenosine 5ยด-tetraphosphate formation | Escherichia coli | |
6.2.1.5 | CoA plus succinate | presence of succinate plus CoA inhibits adenosine 5'-tetraphosphate formation | Escherichia coli | |
6.2.1.5 | succinate | presence of succinate plus CoA inhibits adenosine 5'-tetraphosphate formation | Escherichia coli |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.2.1.5 | 0.0145 | - |
ATP | adenosine 5ยด-tetraphosphate formation | Escherichia coli |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.2.1.5 | Escherichia coli | - |
wild type and mutant H142N | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.2.1.5 | ATP + ATP | - |
Escherichia coli | adenosine 5'-tetraphosphate + ADP | - |
? | |
6.2.1.5 | ATP + succinate + CoA | - |
Escherichia coli | ADP + phosphate + succinyl-CoA | - |
? | |
6.2.1.5 | beta,gamma-methylene-adenosine 5'-triphosphate | - |
Escherichia coli | beta,gamma-methylene-adenosine 5'-tetraphosphate + ? | alpha,gamma-methylene adenosine tetraphosphate | ? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.2.1.5 | additional information | - |
additional information | - |
Escherichia coli |