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Literature summary extracted from

  • Spillantini, M.G.; Sicuteri, F.; Salmon, S.; Malfroy, B.
    Characterization of endopeptidase 3.4.24.11 ( enkephalinase ) activity in human plasma and cerebrospinal fluid (1990), Biochem. Pharmacol., 39, 1353-1356.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.11 Leu5-enkephalin
-
 Homo sapiens
3.4.24.11 Leu5-enkephalin
-
 Mus musculus
3.4.24.11 Leu5-enkephalin hydrolysis of succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide Rattus norvegicus
3.4.24.11 Met5-enkephalin
-
 Homo sapiens
3.4.24.11 Met5-enkephalin
-
 Mus musculus
3.4.24.11 Met5-enkephalin hydrolysis of succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide Rattus norvegicus
3.4.24.11 phosphoramidon
-
 Homo sapiens
3.4.24.11 phosphoramidon
-
 Mus musculus
3.4.24.11 phosphoramidon
-
 Rattus norvegicus
3.4.24.11 thiorphan
-
 Homo sapiens
3.4.24.11 thiorphan
-
 Mus musculus
3.4.24.11 thiorphan
-
 Rattus norvegicus
3.4.24.11 thiorphan-NH2
-
 Homo sapiens
3.4.24.11 thiorphan-NH2
-
 Mus musculus
3.4.24.11 thiorphan-NH2
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.11 0.043
-
 succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide enzyme from amniotic fluid Homo sapiens
3.4.24.11 0.052
-
 succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide
-
 Rattus norvegicus
3.4.24.11 0.054
-
 succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide enzyme from cerebrospinal fluid Homo sapiens
3.4.24.11 0.058
-
 succinyl-Ala-Ala-Phe-AMC plasma enzyme Homo sapiens
3.4.24.11 0.073
-
 succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.11 membrane
-
 Homo sapiens 16020
-
3.4.24.11 membrane bound Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.11 Zinc
-
 Homo sapiens
3.4.24.11 Zinc zinc-containing metalloenzyme Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.11 Homo sapiens
-
-
-
3.4.24.11 Mus musculus
-
-
-
3.4.24.11 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.11 amniotic fluid
-
 Homo sapiens
-
3.4.24.11 cerebrospinal fluid
-
 Homo sapiens
-
3.4.24.11 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.11 succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide + H2O
-
 Mus musculus succinyl-Ala-Ala + Phe-4-methylcoumarin 7-amide
-
 ?
3.4.24.11 succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens succinyl-Ala-Ala + Phe-4-methylcoumarin 7-amide
-
 ?
3.4.24.11 succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide + H2O
-
 Rattus norvegicus succinyl-Ala-Ala + Phe-4-methylcoumarin 7-amide
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.11 7
-
-
 Mus musculus
3.4.24.11 7
-
-
 Homo sapiens
3.4.24.11 7
-
-
 Rattus norvegicus