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Literature summary extracted from

  • Mori, A.; Yamada, K.; Kimura, J.; Koide, J.; Yuasa, S.; Yamada, E.; Miyamura, T.
    Enzymatic characterization of purified NS3 serine proteinase of hepatitis C virus expressed in Escherichia coli (1996), FEBS Lett., 378, 37-42.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.98 expressed in Escherichia coli Hepacivirus C

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.98 1,10-phenanthroline 0.26 mM, 50% inhibition Hepacivirus C
3.4.21.98 3,4-dichloroisocoumarin 0.03 mM, 50% inhibition Hepacivirus C
3.4.21.98 4-(2-aminoethyl)-benzenesulfonyl fluoride 0.45 mM, 50% inhibition Hepacivirus C
3.4.21.98 4-(amidinophenyl)-methanesulfonyl fluoride 1.89 mM, 50% inhibition Hepacivirus C
3.4.21.98 chymostatin 0.71 mM, 50% inhibition Hepacivirus C
3.4.21.98 EDTA 0.007 mM, 50% inhibition Hepacivirus C
3.4.21.98 EGTA 1.6 mM, 50% inhibition Hepacivirus C
3.4.21.98 iodoacetamide 0.26 mM, 50% inhibition Hepacivirus C
3.4.21.98 N-tosyl-Phe chloromethyl ketone 0.03 mM, 50% inhibition Hepacivirus C
3.4.21.98 Nalpha-p-tosyl-Lys chloromethyl ketone 0.15 mM, 50% inhibition Hepacivirus C
3.4.21.98 phenylmethanesulfonyl fluoride 0.6 mM, 50% inhibition Hepacivirus C
3.4.21.98 trans-1,2-cyclohexanediamine-N,N,N',N'-tetraacetic acid 0.007 mM, 50% inhibition Hepacivirus C

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.98 Hepacivirus C
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.98
-
 Hepacivirus C

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.98 37
-
-
 Hepacivirus C

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.98 7.5
-
-
 Hepacivirus C

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.4.21.98 6 9
-
 Hepacivirus C

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.98 0.007
-
 EDTA
-
 Hepacivirus C
3.4.21.98 0.007
-
 trans-1,2-cyclohexanediamine-N,N,N',N'-tetraacetic acid
-
 Hepacivirus C
3.4.21.98 0.03
-
 3,4-dichloroisocoumarin
-
 Hepacivirus C
3.4.21.98 0.03
-
 N-tosyl-Phe chloromethyl ketone
-
 Hepacivirus C
3.4.21.98 0.15
-
 Nalpha-p-tosyl-Lys chloromethyl ketone
-
 Hepacivirus C
3.4.21.98 0.26
-
 1,10-phenanthroline
-
 Hepacivirus C
3.4.21.98 0.26
-
 iodoacetamide
-
 Hepacivirus C
3.4.21.98 0.45
-
 4-(2-aminoethyl)-benzenesulfonyl fluoride
-
 Hepacivirus C
3.4.21.98 0.6
-
 phenylmethanesulfonyl fluoride
-
 Hepacivirus C
3.4.21.98 0.71
-
 chymostatin
-
 Hepacivirus C
3.4.21.98 1.6
-
 EGTA
-
 Hepacivirus C
3.4.21.98 1.89
-
 4-(amidinophenyl)-methanesulfonyl fluoride
-
 Hepacivirus C