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Literature summary extracted from
- Characterization of chicken lung angiotensin I-converting enzyme (1992), J. Endocrinol., 132, 261-268.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | Cl- | activates | Gallus gallus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | angiotensin II | - |
Gallus gallus | |
| 3.4.15.1 | captopril | - |
Gallus gallus | |
| 3.4.15.1 | EDTA | - |
Gallus gallus | |
| 3.4.15.1 | His-Leu | - |
Gallus gallus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.15.1 | 0.065 | - |
angiotensin I | detergent-solubilized enzyme | Gallus gallus | |
| 3.4.15.1 | 0.078 | - |
angiotensin I | trypsin-extracted enzyme | Gallus gallus | |
| 3.4.15.1 | 0.32 | - |
hippuryl-His-Leu | detergent-solubilized enzyme | Gallus gallus | |
| 3.4.15.1 | 0.52 | - |
hippuryl-His-Leu | trypsin-extracted enzyme | Gallus gallus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.15.1 | membrane | - |
Gallus gallus | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | Zinc | contains approximately 1 gatom of zinc per mol of enzyme | Gallus gallus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Gallus gallus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | side-chain modification | glycoprotein | Gallus gallus |
| 3.4.15.1 | side-chain modification | hexoses are the most abundant residues | Gallus gallus |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.15.1 | - |
Gallus gallus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | angiotensin I + H2O | - |
Gallus gallus | angiotensin II + His-Leu | - |
? | |
| 3.4.15.1 | bradykinin + H2O | - |
Gallus gallus | Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe | - |
? | |
| 3.4.15.1 | hippuryl-His-Leu + H2O | - |
Gallus gallus | hippuric acid + His-Leu | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.15.1 | 2.95 | - |
angiotensin I | detergent-solubilized enzyme | Gallus gallus | |
| 3.4.15.1 | 5.4 | - |
hippuryl-His-Leu | detergent-solubilized enzyme | Gallus gallus | |
| 3.4.15.1 | 6.58 | - |
angiotensin I | trypsin-extracted enzyme | Gallus gallus | |
| 3.4.15.1 | 8.58 | - |
hippuryl-His-Leu | trypsin-extracted enzyme | Gallus gallus | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | 8.3 | 8.7 | - |
Gallus gallus |
| 3.4.15.1 | 8.5 | - |
hydrolysis of hippuryl-His-Leu | Gallus gallus |
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