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Literature summary extracted from
- Angiotensin I converting enzyme from human plasma (1977), Biochemistry, 16, 5491-5495.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | Cl- | required | Homo sapiens |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | 3-mercapto-2-D-methylpropanoyl-L-Pro | i.e. SQ-14,225 | Homo sapiens | |
| 3.4.15.1 | angiotensin II | - |
Homo sapiens | |
| 3.4.15.1 | bradykinin | - |
Homo sapiens | |
| 3.4.15.1 | EDTA | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | side-chain modification | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
| 3.4.15.1 | bradykinin + H2O | - |
Homo sapiens | Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe | - |
? | |
| 3.4.15.1 | hippuryl-His-Leu + H2O | - |
Homo sapiens | hippuric acid + His-Leu | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | 8.3 | - |
hydrolysis of hippuryl-His-Leu, potassium phosphate buffer, enzyme form I, II, and III | Homo sapiens |
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