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Literature summary extracted from

  • Nishimura, K.; Yoshida, N.; Hiwada, K.; Ueda, E.; Kokubu, T.
    Properties of three different forms of angiotensin I-converting enzyme from human lung (1978), Biochim. Biophys. Acta, 522, 229-237.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 angiotensin II
-
Homo sapiens
3.4.15.1 Arg-Pro-Pro inhibition of enzyme form I and II, enzyme form III is not inhibited Homo sapiens
3.4.15.1 bradykinin
-
Homo sapiens
3.4.15.1 bradykinin potentiator C inhibition of enzyme form I and II, enzyme form III is not inhibited Homo sapiens
3.4.15.1 EDTA
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.15.1 0.6
-
hippuryl-His-Leu 100 mM borate/sodium carbonate buffer, pH 7.8 Homo sapiens
3.4.15.1 1.1
-
hippuryl-His-Leu 10 mM potassium phosphate buffer, pH 8.3, enzyme form I, II, and III Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.15.1 98000
-
enzyme form III, gel filtration Homo sapiens
3.4.15.1 180000
-
enzyme form II, gel filtration Homo sapiens
3.4.15.1 290000
-
enzyme form I, gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.15.1
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 lung 3 different enzyme forms: I, II, and III Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.15.1 additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
Homo sapiens angiotensin II + His-Leu
-
?
3.4.15.1 bradykinin + H2O
-
Homo sapiens Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
?
3.4.15.1 hippuryl-His-Leu + H2O
-
Homo sapiens hippuric acid + His-Leu
-
?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.15.1 50
-
10 min, enzyme form I and II lose 90% of the hydrolytic activity with hippuryl-His-Leu as substrate, enzyme form III loses 45% of its activity Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.15.1 7.3 8 hydrolysis of hippuryl-His-Leu, borate/sodium carbonate buffer Homo sapiens