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Literature summary extracted from

  • Corvol, P.; Williams, T.A.; Soubrier, F.
    Peptidyl dipeptidase A: angiotensin I-converting enzyme (1995), Methods Enzymol., 248, 283-305.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.15.1 Cl-
-
 Homo sapiens
3.4.15.1 Cl- required for hydrolysis of angiotensin I, not required for hydrolysis of bradykinin Mammalia

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.15.1 somatic enzyme form Mus musculus
3.4.15.1 somatic enzyme form Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 9-[1-carboxy-3-(4-hydroxyphenyl)propylamino]octahydro-10-oxo-6H-pyridazo[1,2-a][1,2]diazepine-1-carboxylic acid
-
 Mammalia
3.4.15.1 captopril i.e. D-(3-mercapto-2-methylpropanoyl)-L-Pro Homo sapiens
3.4.15.1 captopril i.e. D-(3-mercapto-2-methylpropanoyl)-L-Pro Mammalia
3.4.15.1 captopril
-
 Rattus norvegicus
3.4.15.1 enaprilat
-
 Homo sapiens
3.4.15.1 enaprilat i.e. N-[(S)-1-carboxy-3-phenylpropyl]-Ala-Pro Mammalia
3.4.15.1 enaprilat
-
 Rattus norvegicus
3.4.15.1 lisinopril
-
 Homo sapiens
3.4.15.1 lisinopril i.e. N-[(S)-1-carboxy-3-phenylpropyl]-L-Lys-L-Pro Mammalia

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.15.1 additional information
-
 additional information
-
 Mammalia
3.4.15.1 additional information
-
 additional information
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.15.1 membrane anchored to plasma membrane, the bulk of its mass exposed at the extracellular surface of the cell Mammalia 16020
-
3.4.15.1 membrane inserted in plasma membrane via the carboxyl terminus Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.15.1 Zinc
-
 Homo sapiens
3.4.15.1 Zinc required Mammalia

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.15.1 90000 110000 germinal cells, germinal cells also contain an enzyme form of MW 150000-180000 Da, gel filtration Mammalia
3.4.15.1 150000 180000 somatic enzyme form in endothelial, epithelial, neuronal, and germinal cells, in germinal cells a second enzyme form of 90000-110000 Da exists, gel filtration Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 additional information Homo sapiens
-
 ?
-
 ?
3.4.15.1 additional information Rattus norvegicus
-
 ?
-
 ?
3.4.15.1 additional information Mammalia the enzyme enhances presentation of certain endogenously synthesized peptides to major histocompatibility complex class-I-restricted cytotoxic T-lymphocytes ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Homo sapiens
-
-
-
3.4.15.1 Mammalia
-
 two ACE forms: a somatic form of MW 150000-180000 Da and a smaller isoform of MW 90009-110000 Da in germinal cells
-
3.4.15.1 Mus musculus
-
-
-
3.4.15.1 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.15.1 side-chain modification glycoprotein Mammalia
3.4.15.1 side-chain modification glycoprotein Homo sapiens
3.4.15.1 side-chain modification glycoprotein Rattus norvegicus
3.4.15.1 side-chain modification somatic enzyme form contains 17 potential glycosylation sites but no Ser/Thr-rich region indicative of O-glycosylation Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 endothelium
-
 Homo sapiens
-
3.4.15.1 endothelium vascular Mammalia
-
3.4.15.1 epithelium brush border of absorptive epithelia on the small intestine and the renal convoluted tubule Mammalia
-
3.4.15.1 germ
-
 Mammalia
-
3.4.15.1 kidney
-
 Mus musculus
-
3.4.15.1 kidney
-
 Homo sapiens
-
3.4.15.1 kidney
-
 Rattus norvegicus
-
3.4.15.1 lung
-
 Homo sapiens
-
3.4.15.1 lung
-
 Rattus norvegicus
-
3.4.15.1 macrophage
-
 Mammalia
-
3.4.15.1 monocyte
-
 Mammalia
-
3.4.15.1 neuron
-
 Mammalia
-
3.4.15.1 T-lymphocyte
-
 Mammalia
-
3.4.15.1 testis
-
 Mammalia
-
3.4.15.1 testis
-
 Homo sapiens
-
3.4.15.1 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
 Mammalia angiotensin II + His-Leu
-
 ?
3.4.15.1 angiotensin I + H2O
-
 Mus musculus angiotensin II + His-Leu
-
 ?
3.4.15.1 angiotensin I + H2O
-
 Homo sapiens angiotensin II + His-Leu
-
 ?
3.4.15.1 beta-neoendorphin + H2O
-
 Mammalia ?
-
 ?
3.4.15.1 bradykinin + H2O
-
 Mammalia Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
3.4.15.1 bradykinin + H2O
-
 Homo sapiens Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
3.4.15.1 bradykinin + H2O
-
 Rattus norvegicus Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
3.4.15.1 cholecystokinin-8 + H2O
-
 Mammalia ?
-
 ?
3.4.15.1 dynorphin + H2O
-
 Mammalia ?
-
 ?
3.4.15.1 hippuryl-Gly-Gly + H2O
-
 Mammalia hippuric acid + Gly-Gly
-
 ?
3.4.15.1 hippuryl-Gly-Gly + H2O
-
 Homo sapiens hippuric acid + Gly-Gly
-
 ?
3.4.15.1 hippuryl-His-Leu + H2O
-
 Homo sapiens hippuric acid + His-Leu
-
 ?
3.4.15.1 hippuryl-His-Leu + H2O
-
 Rattus norvegicus hippuric acid + His-Leu
-
 ?
3.4.15.1 Met5-enkephalin + H2O
-
 Mammalia Tyr-Gly-Gly + Phe-Met
-
 ?
3.4.15.1 Met5-enkephalin + H2O
-
 Homo sapiens Tyr-Gly-Gly + Phe-Met
-
 ?
3.4.15.1 Met5-enkephalin-Arg6-Gly7-Leu8 + H2O
-
 Mammalia Tyr-Gly-Gly-Phe-met-Arg + Gly-Leu
-
 ?
3.4.15.1 additional information
-
 Homo sapiens ?
-
 ?
3.4.15.1 additional information
-
 Rattus norvegicus ?
-
 ?
3.4.15.1 additional information the enzyme enhances presentation of certain endogenously synthesized peptides to major histocompatibility complex class-I-restricted cytotoxic T-lymphocytes Mammalia ?
-
 ?
3.4.15.1 neurotensin + H2O
-
 Mammalia pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr + Ile-Leu
-
 ?
3.4.15.1 neurotensin + H2O
-
 Homo sapiens pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr + Ile-Leu
-
 ?