Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cushman, D.W.; Cheung, H.S.; Sabo, E.F.; Rubin, B.; Ondetti, M.A.
    Development of specific inhibitors of angiotensin I converting enzyme (kininase II) (1979), Fed. Proc., 38, 2778-2782.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 captopril competitive, of great value for use in chronic therapy of human hypertensive disease Homo sapiens
3.4.15.1 Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro therapeutical useful Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.15.1 Zinc contains zinc Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 additional information Homo sapiens may contribute to elevated blood pressure in hypertensive disease via conversion of angiotensin I to angiotensin II or inactivation of bradykinin ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Homo sapiens
-
-
-
3.4.15.1 Sus scrofa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
 Homo sapiens angiotensin II + His-Leu
-
 ?
3.4.15.1 angiotensin I + H2O
-
 Sus scrofa angiotensin II + His-Leu
-
 ?
3.4.15.1 bradykinin + H2O
-
 Homo sapiens Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
3.4.15.1 bradykinin + H2O
-
 Sus scrofa Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
3.4.15.1 additional information may contribute to elevated blood pressure in hypertensive disease via conversion of angiotensin I to angiotensin II or inactivation of bradykinin Homo sapiens ?
-
 ?