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Literature summary extracted from

  • Schulz, V.; Schmidt-Vogler, C.; Strohmeyer, P.; Weber, S.; Kleemann, D.; Nies, D.; Herzberg, M.
    Behind the shield of Czc ZntR controls expression of the gene for the zinc-exporting P-type ATPase ZntA in cupriavidus metallidurans (2021), J. Bacteriol., 203, e00052-21.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.12 ATP + H2O + Cd2+[side 1] Cupriavidus metallidurans
-
 ADP + phosphate + Cd2+[side 2]
-
 ?
7.2.2.12 ATP + H2O + Cd2+[side 1] Cupriavidus metallidurans ATCC 43123
-
 ADP + phosphate + Cd2+[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.12 Cupriavidus metallidurans Q1LEH0
-
-
7.2.2.12 Cupriavidus metallidurans ATCC 43123 Q1LEH0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.12 ATP + H2O + Cd2+[side 1]
-
 Cupriavidus metallidurans ADP + phosphate + Cd2+[side 2]
-
 ?
7.2.2.12 ATP + H2O + Cd2+[side 1]
-
 Cupriavidus metallidurans ATCC 43123 ADP + phosphate + Cd2+[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.12 zinc-exporting P-type ATPase
-
 Cupriavidus metallidurans
7.2.2.12 ZntA
-
 Cupriavidus metallidurans

General Information

EC Number General Information Comment Organism
7.2.2.12 physiological function the enzyme (ZntA) is responsible for removal of surplus cytoplasmic zinc ions, thereby providing defense against toxic zinc concentrations. Rmet_3456 (ZntR) binds specifically to the zntAp promoter and is the main regulator of zntA expression Cupriavidus metallidurans