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Literature summary extracted from

  • Kapczynski, D.R.; Sweeney, R.; Spackman, E.; Pantin-Jackwood, M.; Suarez, D.L.
    Development of an in vitro model for animal species susceptibility to SARS-CoV-2 replication based on expression of ACE2 and TMPRSS2 in avian cells (2022), Virology, 569, 1-12 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.17.23 medicine expression of both ACE2 and TMPRSS2 genes is necessary to support SARS-CoV-2 infection and replication in DF1 cells and a nonpermissive sub-lineage of MDCK cells. Titers of SARS-CoV-2 in these cell lines are comparable to those observed in control Vero cells. Permissive replication of SARS-CoV-2 is not found in pig or horse. Cells expressing genes from either bat species tested demonstrate temporal replication of SARS-CoV-2 that peaks early and is not sustained Homo sapiens
3.4.21.B60 medicine expression of both ACE2 and TMPRSS2 genes is necessary to support SARS-CoV-2 infection and replication in DF1 cells and a nonpermissive sub-lineage of MDCK cells. Titers of SARS-CoV-2 in these cell lines are comparable to those observed in control Vero cells Mesocricetus auratus
3.4.21.B60 medicine expression of both ACE2 and TMPRSS2 genes is necessary to support SARS-CoV-2 infection and replication in DF1 cells and a nonpermissive sub-lineage of MDCK cells. Titers of SARS-CoV-2 in these cell lines are comparable to those observed in control Vero cells Felis catus
3.4.21.B60 medicine expression of both ACE2 and TMPRSS2 genes is necessary to support SARS-CoV-2 infection and replication in DF1 cells and a nonpermissive sub-lineage of MDCK cells. Titers of SARS-CoV-2 in these cell lines are comparable to those observed in control Vero cells Capra hircus
3.4.21.B60 medicine expression of both ACE2 and TMPRSS2 genes is necessary to support SARS-CoV-2 infection and replication in DF1 cells and a nonpermissive sub-lineage of MDCK cells. Titers of SARS-CoV-2 in these cell lines are comparable to those observed in control Vero cells. Permissive replication of SARS-CoV-2 is not found in pig or horse. Cells expressing genes from either bat species tested demonstrate temporal replication of SARS-CoV-2 that peaks early and is not sustained Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.23 expression in the avian fibroblast cell line, DF1 Homo sapiens
3.4.21.B60 expression in in the avian fibroblast cell line, DF1 Mesocricetus auratus
3.4.21.B60 expression in in the avian fibroblast cell line, DF1 Felis catus
3.4.21.B60 expression in in the avian fibroblast cell line, DF1 Homo sapiens
3.4.21.B60 expression in in the avian fibroblast cell line, DF1 Capra hircus

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens Q9BYF1
-
-
3.4.21.B60 Capra hircus A0A452FYA6
-
-
3.4.21.B60 Felis catus Q56H28
-
-
3.4.21.B60 Homo sapiens O15393
-
-
3.4.21.B60 Mesocricetus auratus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B60 TMPRSS2
-
 Mesocricetus auratus
3.4.21.B60 TMPRSS2
-
 Felis catus
3.4.21.B60 TMPRSS2
-
 Capra hircus