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Literature summary extracted from
- Identification of novel thiadiazin derivatives as potentially selective inhibitors towards trypanothione reductase from Trypanosoma cruzi by molecular docking using the numerical index poses ratio Pr and the binding mode analysis (2021), SN Appl. Sci., 3, 376 .
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.12 | additional information | a virtual screening of a library of thiadiazine derivatives against trypanothione reductase using molecular docking is performed. Thiadiazine-based compounds are identified as plausible candidates to selectively inhibit the parasitic enzyme | Trypanosoma cruzi |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.12 | Trypanosoma cruzi | P28593 | - |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.12 | trypanothione reductase | - |
Trypanosoma cruzi |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.8.1.12 | physiological function | the enzyme plays a central role in the metabolic pathway of the parasite | Trypanosoma cruzi |
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Release 2023.1 (January 2023)
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