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Literature summary extracted from

  • Liu, J.; Wei, Y.; Ma, K.; An, J.; Liu, X.; Liu, Y.; Ang, E.; Zhao, H.; Zhang, Y.
    Mechanistically diverse pathways for sulfoquinovose degradation in bacteria (2021), ACS Catal., 11, 14740-14750 .
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.433 2-sulfoacetaldehyde + NADH + H+ Clostridium sp. MSTE9
-
 isethionate + NAD+
-
 r
1.1.1.433 isethionate + NAD+ Clostridium sp. MSTE9
-
 2-sulfoacetaldehyde + NADH + H+
-
 r
2.2.1.15 4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde-3-phosphate Clostridium sp. MSTE9
-
 D-xylulose-5-phosphate + sulfoacetaldehyde
-
 ?
2.2.1.15 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde-3-phosphate Clostridium sp. MSTE9
-
 D-xylulose-5-phosphate + 4-deoxy-4-sulfo-D-erythrose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.432 Novosphingobium aromaticivorans
-
-
-
1.1.1.433 Clostridium sp. MSTE9
-
-
-
2.2.1.15 Clostridium sp. MSTE9
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.432 6-dehydro-D-glucose + NADPH + H+
-
 Novosphingobium aromaticivorans D-glucose + NADP+
-
 r
1.1.1.432 D-glucose + NADP+
-
 Novosphingobium aromaticivorans 6-dehydro-D-glucose + NADPH + H+
-
 r
1.1.1.433 2-sulfoacetaldehyde + NADH + H+
-
 Clostridium sp. MSTE9 isethionate + NAD+
-
 r
1.1.1.433 isethionate + NAD+
-
 Clostridium sp. MSTE9 2-sulfoacetaldehyde + NADH + H+
-
 r
2.2.1.15 4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde-3-phosphate
-
 Clostridium sp. MSTE9 D-xylulose-5-phosphate + sulfoacetaldehyde
-
 ?
2.2.1.15 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde-3-phosphate
-
 Clostridium sp. MSTE9 D-xylulose-5-phosphate + 4-deoxy-4-sulfo-D-erythrose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.432 squF
-
 Novosphingobium aromaticivorans
1.1.1.433 sqwF
-
 Clostridium sp. MSTE9
2.2.1.15 sqwGH
-
 Clostridium sp. MSTE9

General Information

EC Number General Information Comment Organism
1.1.1.432 physiological function in Novosphingobium aromaticivorans, sulfoquinovose degradation involves oxygenolytic C-S cleavage by flavin-dependent alkanesulfonate monooxygenase SquD that catalyzes sulfoquinovose cleavage into sulfite and 6-dehydro-D-glucose. SquF is an NAD(P)-dependent D-glucose 6-dehydrogenase Novosphingobium aromaticivorans
1.1.1.433 evolution in diverse anaerobic bacteria including Firmicutes, Tenericutes, Spirochaetes, and Thermotogae bacteria, a sulfoquinone degradation pathway contains a mutarotase SqvB, an isomerase SqvD, a transketolase SqwGH, a homologue of ribose-5-phosphate isomerase SqwI, a metal-dependent alcohol dehydrogenase SqwF, and a member of the sulfite/sulfonate exporter family SqwE. This suggests a pathway involving isomerization of sulfoquinone to 6-deoxy-6-sulfofructose by SqvD, cleavage of 6-deoxy-6-sulfofructose by SqwGH, reduction of an aldehyde-containing sulfonate by SqwF, followed by export of the sulfonate end-product by SqwE Clostridium sp. MSTE9
2.2.1.15 evolution in diverse anaerobic bacteria including Firmicutes, Tenericutes, Spirochaetes, and Thermotogae bacteria, a sulfoquinone degradation pathway contains a mutarotase SqvB, an isomerase SqvD, a transketolase SqwGH, a homologue of ribose-5-phosphate isomerase SqwI, a metal-dependent alcohol dehydrogenase SqwF, and a member of the sulfite/sulfonate exporter family SqwE. This suggests a pathway involving isomerization of sulfoquinone to 6-deoxy-6-sulfofructose by SqvD, cleavage of 6-deoxy-6-sulfofructose by SqwGH, reduction of an aldehyde-containing sulfonate by SqwF, followed by export of the sulfonate end-product by SqwE Clostridium sp. MSTE9