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Literature summary extracted from
- In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus origin (2021), Sci. Rep., 11, 13063 .
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.17.23 | Bos taurus | Q2HJI5 | angiotensin-converting enzyme 2 precursor | - |
| 3.4.17.23 | Canis lupus familiaris | J9P7Y2 | - |
- |
| 3.4.17.23 | Equus caballus | F6V9L3 | - |
- |
| 3.4.17.23 | Felis catus | Q56H28 | - |
- |
| 3.4.17.23 | Homo sapiens | Q9BYF1 | - |
- |
| 3.4.17.23 | Macaca fascicularis | A0A2K5X283 | - |
- |
| 3.4.17.23 | Manis javanica | XP_017505752.1 | - |
- |
| 3.4.17.23 | Mesocricetus auratus | A0A1U7QTA1 | - |
- |
| 3.4.17.23 | Mus musculus | Q8R0I0 | - |
- |
| 3.4.17.23 | Mustela putorius furo | Q2WG88 | - |
- |
| 3.4.17.23 | Ophiophagus hannah | V8NIH2 | - |
- |
| 3.4.17.23 | Paguma larvata | Q56NL1 | - |
- |
| 3.4.17.23 | Panthera tigris | XP_007090142 | - |
- |
| 3.4.17.23 | Rhinolophus sinicus | U5WHY8 | - |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.17.23 | ACE2 | - |
Homo sapiens |
| 3.4.17.23 | ACE2 | - |
Mus musculus |
| 3.4.17.23 | ACE2 | - |
Rhinolophus sinicus |
| 3.4.17.23 | ACE2 | - |
Paguma larvata |
| 3.4.17.23 | ACE2 | - |
Manis javanica |
| 3.4.17.23 | ACE2 | - |
Felis catus |
| 3.4.17.23 | ACE2 | - |
Macaca fascicularis |
| 3.4.17.23 | ACE2 | - |
Panthera tigris |
| 3.4.17.23 | ACE2 | - |
Bos taurus |
| 3.4.17.23 | ACE2 | - |
Mesocricetus auratus |
| 3.4.17.23 | ACE2 | - |
Equus caballus |
| 3.4.17.23 | ACE2 | - |
Mustela putorius furo |
| 3.4.17.23 | ACE2 | - |
Canis lupus familiaris |
| 3.4.17.23 | ACE2 | - |
Ophiophagus hannah |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Homo sapiens |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Mus musculus |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Rhinolophus sinicus |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Paguma larvata |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Manis javanica |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Felis catus |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Macaca fascicularis |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Panthera tigris |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Bos taurus |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Mesocricetus auratus |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Equus caballus |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Mustela putorius furo |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Canis lupus familiaris |
| 3.4.17.23 | evolution | Spike protein of SARS-CoV-2 exhibits the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Pangolin (Manis javanica) ACE2 shows the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 is much lower despite its high sequence similarity to hACE2. ACE2 species in the upper half of the predicted affinity range (Macaca fascicularis, Mesocricetus auratus, Canis luparis, Mustela putorius furot, Felis catus) are permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility | Ophiophagus hannah |
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Release 2023.1 (January 2023)
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