Any feedback?
Literature summary extracted from
- Non-hydroxamate inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) a critical review and future perspective (2021), Eur. J. Med. Chem., 213, 113055 .
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.1.1.267 | drug development | enzyme DXR is an antimicrobial target | Escherichia coli |
| 1.1.1.267 | drug development | enzyme DXR is an antimicrobial target | Plasmodium falciparum |
| 1.1.1.267 | drug development | enzyme DXR is an antimicrobial target | Mycobacterium tuberculosis |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.267 | (2-[[hydroxy(methyl)carbamoyl]oxy]ethyl)phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | (3-acetamidopropyl)phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | (3-boronopropyl)phosphonic acid | MIC90 = 0.053 mg/ml | Escherichia coli | |
| 1.1.1.267 | (4-hydrazinyl-4-oxobutyl)phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | ([[acetyl(hydroxy)amino]methoxy]methyl)phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | ([[acetyl(hydroxy)amino]methoxy]methyl)phosphonic acid | - |
Plasmodium falciparum | |
| 1.1.1.267 | ([[formyl(hydroxy)amino]methoxy]methyl)phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | ([[formyl(hydroxy)amino]methoxy]methyl)phosphonic acid | - |
Plasmodium falciparum | |
| 1.1.1.267 | 1-hydroxy-5-phenylpyridin-2(1H)-one | - |
Escherichia coli |  |
| 1.1.1.267 | 2-[acetyl(hydroxy)amino]ethyl phosphate | - |
Escherichia coli | |
| 1.1.1.267 | 2-[acetyl(hydroxy)amino]ethyl phosphate | - |
Mycobacterium tuberculosis | |
| 1.1.1.267 | 2-[formyl(hydroxy)amino]ethyl phosphate | - |
Escherichia coli | |
| 1.1.1.267 | 2-[formyl(hydroxy)amino]ethyl phosphate | - |
Mycobacterium tuberculosis | |
| 1.1.1.267 | 4-benzylbenzene-1,2-diol | - |
Escherichia coli | |
| 1.1.1.267 | 5-[hydroxy(methyl)amino]-5-oxopentanoic acid | - |
Escherichia coli | |
| 1.1.1.267 | diethyl (2-[[(furan-2-yl)methyl]amino]-2-oxoethyl)phosphonate | - |
Escherichia coli | |
| 1.1.1.267 | diethyl [2-(3-hydroxyanilino)-2-oxoethyl]phosphonate | 43.9% inhibition at 0.25 mM | Escherichia coli | |
| 1.1.1.267 | diethyl [2-(3-hydroxyanilino)-2-oxoethyl]phosphonate | 45.2% inhibition at 0.25 mM | Plasmodium falciparum | |
| 1.1.1.267 | diethyl [2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl]phosphonate | - |
Escherichia coli | |
| 1.1.1.267 | diethyl [2-oxo-2-[(pyridin-2-yl)amino]ethyl]phosphonate | - |
Escherichia coli | |
| 1.1.1.267 | diethyl [2-[3-(hydroxymethyl)anilino]-2-oxoethyl]phosphonate | 40.4% inhibition at 0.25 mM | Escherichia coli | |
| 1.1.1.267 | diethyl [2-[3-(hydroxymethyl)anilino]-2-oxoethyl]phosphonate | 40.7% inhibition at 0.25 mM | Plasmodium falciparum | |
| 1.1.1.267 | diethyl [3-(3-hydroxyanilino)-3-oxopropyl]phosphonate | 49.2% inhibition at 0.25 mM | Escherichia coli | |
| 1.1.1.267 | diethyl [3-[3-(hydroxymethyl)anilino]-3-oxopropyl]phosphonate | 17.9% inhibition at 0.25 mM | Escherichia coli | |
| 1.1.1.267 | fosmidomycin | a natural product, which forms a chelate with the active site divalent metal ion (Mg2+/Mn2+) through its hydroxamate metal-binding group. Competitive versus 1-deoxy-D-xylulose 5-phosphate, uncompetitive versus NADPH, strong inhibition | Escherichia coli | |
| 1.1.1.267 | fosmidomycin | a natural product, which forms a chelate with the active site divalent metal ion (Mg2+/Mn2+) through its hydroxamate metal-binding group. Competitive versus 1-deoxy-D-xylulose 5-phosphate, uncompetitive versus NADPH | Mycobacterium tuberculosis | |
| 1.1.1.267 | fosmidomycin | a natural product, which forms a chelate with the active site divalent metal ion (Mg2+/Mn2+) through its hydroxamate metal-binding group. Competitive versus 1-deoxy-D-xylulose 5-phosphate, uncompetitive versus NADPH. No or poor inhibition by diethyl [3-[3-(hydroxymethyl)anilino]-3-oxopropyl]phosphonate, diethyl [3-(3-hydroxyanilino)-3-oxopropyl]phosphonate, and [3-(3-methoxyanilino)-3-oxopropyl]phosphonic acid | Plasmodium falciparum | |
| 1.1.1.267 | FR-900098 | - |
Escherichia coli | |
| 1.1.1.267 | FR-900098 | - |
Mycobacterium tuberculosis | |
| 1.1.1.267 | FR-900098 | - |
Plasmodium falciparum | |
| 1.1.1.267 | additional information | non-hydroxamate inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), docking study, structure-activity analysis, overview. No inhibiton at 0.02 mM by [3-(3-methoxyanilino)-3-oxopropyl]phosphonic acid or [3-[benzyl(pyridin-2-yl)amino]-3-oxopropyl]phosphonic acid or [3-[benzyl(3-hydroxyphenyl)amino]-3-oxopropyl]phosphonic acid or [2-[(sulfanylcarbonothioyl)amino]ethyl]phosphonic acid or [3-[(sulfanylcarbonothioyl)amino]propyl]phosphonic acid or [3-(2,3-dihydroxyphenyl)propyl]phosphonic acid | Escherichia coli | |
| 1.1.1.267 | additional information | non-hydroxamate inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), docking study, structure-activity analysis, overview | Mycobacterium tuberculosis | |
| 1.1.1.267 | additional information | non-hydroxamate inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), docking study, structure-activity analysis, overview | Plasmodium falciparum | |
| 1.1.1.267 | [(3,4-dichlorophenyl)([2-[hydroxy(methyl)amino]-2-oxoethyl]sulfanyl)methyl]phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | [(3,4-dichlorophenyl)([2-[hydroxy(methyl)amino]-2-oxoethyl]sulfanyl)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
| 1.1.1.267 | [(3,4-dichlorophenyl)([2-[hydroxy(methyl)amino]-2-oxoethyl]sulfanyl)methyl]phosphonic acid | - |
Plasmodium falciparum | |
| 1.1.1.267 | [(5-phenylpyridin-2-yl)methyl]phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | [(quinolin-2-yl)methyl]phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | [1,1'-biphenyl]-3,4-diol | - |
Escherichia coli | |
| 1.1.1.267 | [1-(3,4-dichlorophenyl)-3-[formyl(hydroxy)amino]propyl]phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | [1-(3,4-dichlorophenyl)-3-[formyl(hydroxy)amino]propyl]phosphonic acid | conformation of inhibitor within the MtDXR active site (PDB ID 2Y1D) | Mycobacterium tuberculosis | |
| 1.1.1.267 | [1-(3,4-dichlorophenyl)-3-[formyl(hydroxy)amino]propyl]phosphonic acid | inhibition of strain D2d | Plasmodium falciparum | |
| 1.1.1.267 | [2-(1-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)ethyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
| 1.1.1.267 | [2-(2,3-dihydroxyphenyl)ethyl]phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | [2-(3-hydroxy-4-methylphenyl)ethyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
| 1.1.1.267 | [2-(3-methoxyanilino)-2-oxoethyl]phosphonic acid | 17.8% inhibition at 0.25 mM | Escherichia coli | |
| 1.1.1.267 | [2-[(hydroxycarbamoyl)oxy]ethyl]phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | [2-[acetyl(hydroxy)amino]ethyl]phosphonic acid | 74% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
| 1.1.1.267 | [3-(6-methyl-4,8-dioxo-1,3,6,2-dioxazaborocan-2-yl)propyl]phosphonic acid | MIC90 = 0.063 mg/ml | Escherichia coli | |
| 1.1.1.267 | [3-oxo-3-[(prop-2-yn-1-yl)amino]propyl]phosphonic acid | 6.7% inhibition at 0.020 mM | Escherichia coli | |
| 1.1.1.267 | [3-[acetyl(hydroxy)amino]-1-(3,4-dichlorophenyl)propyl]phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | [3-[acetyl(hydroxy)amino]-1-(3,4-dichlorophenyl)propyl]phosphonic acid | inhibition of strain D2d | Plasmodium falciparum | |
| 1.1.1.267 | [4-(2-acetylanilino)-4-oxobutyl]phosphonic acid | - |
Plasmodium falciparum | |
| 1.1.1.267 | [4-(2-fluoroanilino)-4-oxobutyl]phosphonic acid | - |
Plasmodium falciparum | |
| 1.1.1.267 | [4-(hydroxyamino)-4-oxobutyl]phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | [4-(methoxyamino)-4-oxobutyl]phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | [4-[2-(methanesulfonyl)anilino]-4-oxobutyl]phosphonic acid | - |
Plasmodium falciparum | |
| 1.1.1.267 | [4-[acetyl(hydroxy)amino]butyl]phosphonic acid | 80% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
| 1.1.1.267 | [4-[hydroxy(methyl)amino]-4-oxobutyl]phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | [4-[methoxy(methyl)amino]-4-oxobutyl]phosphonic acid | - |
Escherichia coli | |
| 1.1.1.267 | [[(isoquinolin-1-yl)amino]methylene]bis(phosphonic acid) | - |
Escherichia coli |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.267 | Mg2+ | active site divalent metal ion | Escherichia coli | |
| 1.1.1.267 | Mg2+ | active site divalent metal ion | Plasmodium falciparum | |
| 1.1.1.267 | Mg2+ | active site divalent metal ion | Mycobacterium tuberculosis | |
| 1.1.1.267 | Mn2+ | active site divalent metal ion | Escherichia coli | |
| 1.1.1.267 | Mn2+ | active site divalent metal ion | Plasmodium falciparum | |
| 1.1.1.267 | Mn2+ | active site divalent metal ion | Mycobacterium tuberculosis | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | Escherichia coli | - |
2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | Plasmodium falciparum | - |
2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | Mycobacterium tuberculosis | - |
2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | Mycobacterium tuberculosis H37Rv | - |
2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | Mycobacterium tuberculosis ATCC 25618 | - |
2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.267 | Escherichia coli | P45568 | - |
- |
| 1.1.1.267 | Mycobacterium tuberculosis | P9WNS1 | - |
- |
| 1.1.1.267 | Mycobacterium tuberculosis ATCC 25618 | P9WNS1 | - |
- |
| 1.1.1.267 | Mycobacterium tuberculosis H37Rv | P9WNS1 | - |
- |
| 1.1.1.267 | Plasmodium falciparum | Q8IKG4 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | - |
Escherichia coli | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | - |
Plasmodium falciparum | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | - |
Mycobacterium tuberculosis | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | - |
Mycobacterium tuberculosis H37Rv | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | - |
Mycobacterium tuberculosis ATCC 25618 | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | - |
Escherichia coli |
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | - |
Plasmodium falciparum |
| 1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | - |
Mycobacterium tuberculosis |
| 1.1.1.267 | DXR | - |
Escherichia coli |
| 1.1.1.267 | DXR | - |
Plasmodium falciparum |
| 1.1.1.267 | DXR | - |
Mycobacterium tuberculosis |
| 1.1.1.267 | EcDXR | - |
Escherichia coli |
| 1.1.1.267 | MtDXR | - |
Mycobacterium tuberculosis |
| 1.1.1.267 | PfDXR | - |
Plasmodium falciparum |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.267 | NADP+ | - |
Escherichia coli | |
| 1.1.1.267 | NADP+ | - |
Plasmodium falciparum | |
| 1.1.1.267 | NADP+ | - |
Mycobacterium tuberculosis | |
| 1.1.1.267 | NADPH | - |
Escherichia coli | |
| 1.1.1.267 | NADPH | - |
Plasmodium falciparum | |
| 1.1.1.267 | NADPH | - |
Mycobacterium tuberculosis | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.267 | 6.5 | - |
(3-acetamidopropyl)phosphonic acid | pH and temperature not specified in the publication | Escherichia coli |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.267 | 0.0000045 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | [(3,4-dichlorophenyl)([2-[hydroxy(methyl)amino]-2-oxoethyl]sulfanyl)methyl]phosphonic acid | |
| 1.1.1.267 | 0.0000059 | - |
pH and temperature not specified in the publication | Escherichia coli | [(3,4-dichlorophenyl)([2-[hydroxy(methyl)amino]-2-oxoethyl]sulfanyl)methyl]phosphonic acid | |
| 1.1.1.267 | 0.000008 | - |
pH and temperature not specified in the publication | Escherichia coli | fosmidomycin | |
| 1.1.1.267 | 0.0000092 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | [(3,4-dichlorophenyl)([2-[hydroxy(methyl)amino]-2-oxoethyl]sulfanyl)methyl]phosphonic acid | |
| 1.1.1.267 | 0.000018 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | FR-900098 | |
| 1.1.1.267 | 0.000028 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | [1-(3,4-dichlorophenyl)-3-[formyl(hydroxy)amino]propyl]phosphonic acid | |
| 1.1.1.267 | 0.00003 | - |
pH and temperature not specified in the publication | Escherichia coli | FR-900098 | |
| 1.1.1.267 | 0.000036 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | fosmidomycin | |
| 1.1.1.267 | 0.000048 | - |
pH and temperature not specified in the publication | Escherichia coli | [4-[hydroxy(methyl)amino]-4-oxobutyl]phosphonic acid | |
| 1.1.1.267 | 0.000059 | - |
pH and temperature not specified in the publication | Escherichia coli | [1-(3,4-dichlorophenyl)-3-[formyl(hydroxy)amino]propyl]phosphonic acid | |
| 1.1.1.267 | 0.000077 | - |
pH and temperature not specified in the publication | Escherichia coli | 2-[acetyl(hydroxy)amino]ethyl phosphate | |
| 1.1.1.267 | 0.00008 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | fosmidomycin | |
| 1.1.1.267 | 0.000087 | - |
pH and temperature not specified in the publication | Escherichia coli | ([[acetyl(hydroxy)amino]methoxy]methyl)phosphonic acid | |
| 1.1.1.267 | 0.00009 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | [3-[acetyl(hydroxy)amino]-1-(3,4-dichlorophenyl)propyl]phosphonic acid | |
| 1.1.1.267 | 0.000119 | - |
pH and temperature not specified in the publication | Escherichia coli | [3-[acetyl(hydroxy)amino]-1-(3,4-dichlorophenyl)propyl]phosphonic acid | |
| 1.1.1.267 | 0.00016 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | FR-900098 | |
| 1.1.1.267 | 0.00017 | - |
pH and temperature not specified in the publication | Escherichia coli | [4-(hydroxyamino)-4-oxobutyl]phosphonic acid | |
| 1.1.1.267 | 0.000279 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 2-[acetyl(hydroxy)amino]ethyl phosphate | |
| 1.1.1.267 | 0.000342 | - |
pH and temperature not specified in the publication | Escherichia coli | 2-[formyl(hydroxy)amino]ethyl phosphate | |
| 1.1.1.267 | 0.00036 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | ([[acetyl(hydroxy)amino]methoxy]methyl)phosphonic acid | |
| 1.1.1.267 | 0.00084 | - |
pH and temperature not specified in the publication | Escherichia coli | [(5-phenylpyridin-2-yl)methyl]phosphonic acid | |
| 1.1.1.267 | 0.0011 | - |
pH and temperature not specified in the publication | Escherichia coli | ([[formyl(hydroxy)amino]methoxy]methyl)phosphonic acid | |
| 1.1.1.267 | 0.0014 | - |
pH and temperature not specified in the publication | Escherichia coli | 1-hydroxy-5-phenylpyridin-2(1H)-one | |
| 1.1.1.267 | 0.0021 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 2-[formyl(hydroxy)amino]ethyl phosphate | |
| 1.1.1.267 | 0.003 | - |
above, pH and temperature not specified in the publication | Escherichia coli | (2-[[hydroxy(methyl)carbamoyl]oxy]ethyl)phosphonic acid | |
| 1.1.1.267 | 0.003 | - |
above, pH and temperature not specified in the publication | Escherichia coli | [2-[(hydroxycarbamoyl)oxy]ethyl]phosphonic acid | |
| 1.1.1.267 | 0.004 | - |
pH and temperature not specified in the publication | Escherichia coli | [[(isoquinolin-1-yl)amino]methylene]bis(phosphonic acid) | |
| 1.1.1.267 | 0.0049 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | ([[formyl(hydroxy)amino]methoxy]methyl)phosphonic acid | |
| 1.1.1.267 | 0.0159 | - |
pH and temperature not specified in the publication | Escherichia coli | [(quinolin-2-yl)methyl]phosphonic acid | |
| 1.1.1.267 | 0.0224 | - |
pH and temperature not specified in the publication | Escherichia coli | 4-benzylbenzene-1,2-diol | |
| 1.1.1.267 | 0.025 | - |
pH and temperature not specified in the publication | Escherichia coli | 5-[hydroxy(methyl)amino]-5-oxopentanoic acid | |
| 1.1.1.267 | 0.041 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | [2-(3-hydroxy-4-methylphenyl)ethyl]phosphonic acid | |
| 1.1.1.267 | 0.0447 | - |
pH and temperature not specified in the publication | Escherichia coli | [1,1'-biphenyl]-3,4-diol | |
| 1.1.1.267 | 0.053 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | [2-(1-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)ethyl]phosphonic acid | |
| 1.1.1.267 | 0.064 | - |
above, pH and temperature not specified in the publication | Plasmodium falciparum | [4-(2-acetylanilino)-4-oxobutyl]phosphonic acid | |
| 1.1.1.267 | 0.064 | - |
above, pH and temperature not specified in the publication | Plasmodium falciparum | [4-(2-fluoroanilino)-4-oxobutyl]phosphonic acid | |
| 1.1.1.267 | 0.064 | - |
above, pH and temperature not specified in the publication | Plasmodium falciparum | [4-[2-(methanesulfonyl)anilino]-4-oxobutyl]phosphonic acid | |
| 1.1.1.267 | 0.408 | - |
pH and temperature not specified in the publication | Escherichia coli | diethyl (2-[[(furan-2-yl)methyl]amino]-2-oxoethyl)phosphonate | |
| 1.1.1.267 | 0.472 | - |
pH and temperature not specified in the publication | Escherichia coli | diethyl [2-oxo-2-[(pyridin-2-yl)amino]ethyl]phosphonate | |
| 1.1.1.267 | 0.73 | - |
pH and temperature not specified in the publication | Escherichia coli | diethyl [2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl]phosphonate | |
| 1.1.1.267 | 0.93 | - |
pH and temperature not specified in the publication | Escherichia coli | [4-(methoxyamino)-4-oxobutyl]phosphonic acid | |
| 1.1.1.267 | 1 | - |
pH and temperature not specified in the publication | Escherichia coli | (4-hydrazinyl-4-oxobutyl)phosphonic acid | |
| 1.1.1.267 | 1.2 | - |
pH and temperature not specified in the publication | Escherichia coli | [2-(2,3-dihydroxyphenyl)ethyl]phosphonic acid | |
| 1.1.1.267 | 3.8 | - |
pH and temperature not specified in the publication | Escherichia coli | [4-[methoxy(methyl)amino]-4-oxobutyl]phosphonic acid |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.1.1.267 | malfunction | DXR is essential for the survival of the pathogen, and its inhibition leads to the antimalarial action | Plasmodium falciparum |
| 1.1.1.267 | malfunction | DXR is essential for the survival of the pathogen, and its inhibition leads to the antitubercular action | Mycobacterium tuberculosis |
| 1.1.1.267 | metabolism | 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) catalyzes the second step of the nonmevalonate (or MEP) pathway that functions in several organisms and plants for the synthesis of isoprenoids | Escherichia coli |
| 1.1.1.267 | metabolism | 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) catalyzes the second step of the nonmevalonate (or MEP) pathway that functions in several organisms and plants for the synthesis of isoprenoids | Plasmodium falciparum |
| 1.1.1.267 | metabolism | 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) catalyzes the second step of the nonmevalonate (or MEP) pathway that functions in several organisms and plants for the synthesis of isoprenoids | Mycobacterium tuberculosis |
| 1.1.1.267 | physiological function | DXR is essential for the survival of multiple pathogenic bacteria/parasites | Escherichia coli |
| 1.1.1.267 | physiological function | DXR is essential for the survival of multiple pathogenic bacteria/parasites, including those that cause tuberculosis and malaria in humans | Plasmodium falciparum |
| 1.1.1.267 | physiological function | DXR is essential for the survival of multiple pathogenic bacteria/parasites, including those that cause tuberculosis and malaria in humans | Mycobacterium tuberculosis |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
