EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.86 | - |
Mycobacterium tuberculosis |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.1.1.86 | hanging drop method | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.86 | 6-hydroxy-2-methylthiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione | NSC116565, potent time-dependent inhibitor. The inhibitor binds to Mycobacterium tuberculosis KARI in the presence and absence of the cofactor, NADPH. Inhibits the growth of Mycobacterium tuberculosis H37Ra strain with MIC50 value of 0.00293 mM; NSC116565, potent time-dependent inhibitor. The inhibitor binds to Mycobacterium tuberculosis KARI in the presence and absence of the cofactor, NADPH. Inhibits the growth of Mycobacterium tuberculosis H37Rv strain with MIC50 value of 0.00606 mM | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.86 | Mycobacterium tuberculosis | A5U713 | - |
- |
1.1.1.86 | Mycobacterium tuberculosis | P9WKJ7 | - |
- |
1.1.1.86 | Mycobacterium tuberculosis H37Rv | P9WKJ7 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.86 | - |
Mycobacterium tuberculosis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.86 | (2S)-2-acetolactate + NADPH + H+ | - |
Mycobacterium tuberculosis | (2R)-2,3-dihydroxyisovalerate + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.86 | KARI | - |
Mycobacterium tuberculosis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.86 | NADPH | - |
Mycobacterium tuberculosis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.86 | drug target | the enzyme is a TB drug target | Mycobacterium tuberculosis |
1.1.1.86 | drug target | the enzyme is a TB drug target and 6-hydroxy-2-methylthiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione (NSC116565) is a promising lead for anti-TB drug development | Mycobacterium tuberculosis |
1.1.1.86 | metabolism | second enzyme in the branched chain amino acid biosynthesis pathway | Mycobacterium tuberculosis |