EC Number | Application | Comment | Organism |
---|---|---|---|
1.1.3.18 | synthesis | enzyme cartalyzes selective oxidation of several secondary (S)-alcohols, so the (R)-alcohols are obtained from racemic mixtures in high enantiopurity | Phanerodontia chrysosporium |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.1.3.18 | in silico docking studies. Several hydrophobic and aromatic residues in the substrate binding site create a cavity in which the substrates can comfortably undergo van der Waals and pi-stacking interactions. Consequently, oxidation of the secondary alcohols is restricted to one of the two enantiomers | Phanerodontia chrysosporium |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.1.3.18 | F101S | variant is less capable of converting the (S)-alcohols and does not convert any of the (R)-alcohols | Phanerodontia chrysosporium |
1.1.3.18 | L317F | mutant displays low or no significant activity with secondary alcohols and/or lower enantioselectivity than wild-type | Phanerodontia chrysosporium |
1.1.3.18 | T315S | mutant displays low or no significant activity with secondary alcohols and/or lower enantioselectivity than wild-type | Phanerodontia chrysosporium |
1.1.3.18 | W560F | mutant displays low or no significant activity with secondary alcohols and/or lower enantioselectivity than wild-type | Phanerodontia chrysosporium |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.3.13 | Phanerodontia chrysosporium | T2M2J4 | - |
- |
1.1.3.18 | Phanerodontia chrysosporium | T2M2J4 | cf. EC 1.1.3.13 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.3.13 | additional information | enzyme additionally acts on secondary alcohols, reaction of EC 1.1.3.18. By selective oxidation of the (S)-alcohols, the (R)-alcohols can be obtained in high enantiopurity | Phanerodontia chrysosporium | ? | - |
- |
|
1.1.3.18 | 1-indanol + O2 | - |
Phanerodontia chrysosporium | 1-indanone + H2O2 | - |
? | |
1.1.3.18 | 1-phenylethanol + O2 | - |
Phanerodontia chrysosporium | 1-phenylthanone + H2O2 | - |
? | |
1.1.3.18 | 2-pentanol + O2 | - |
Phanerodontia chrysosporium | 2-pentanone + H2O2 | - |
? | |
1.1.3.18 | 3-butyn-2-ol + O2 | - |
Phanerodontia chrysosporium | 3-butyn-2-one + H2O2 | - |
? | |
1.1.3.18 | additional information | enzyme acts both on secondary alcohols, and on primary alcohols, reaction of EC 1.1.3.13. By selective oxidation of the (S)-alcohols, the (R)-alcohols can be obtained in high enantiopurity | Phanerodontia chrysosporium | ? | - |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.3.18 | AOX1 | - |
Phanerodontia chrysosporium |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.3.18 | FAD | - |
Phanerodontia chrysosporium |