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Literature summary extracted from

  • Zhang, D.; Liu, Y.; Cui, Y.; Cui, S.
    Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) mediates the LH-induced stimulation of progesterone synthesis in the porcine corpus luteum (2019), Reprod. Fertil. Dev., 31, 1444-1456 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.25 Tpl2 kinase inhibitor inhibitory at 0.01 mM Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.25 ATP + ERK1/2 Sus scrofa
-
 ADP + phosphorylated ERK1/2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.25 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.25 adrenal gland
-
 Sus scrofa
-
2.7.11.25 corpus luteum highest expression. In pigs, isoform MAP3K8 expression is higher in mature corpus luteums (or those of the mid-luteal phase) than in regressing corpus luteums (late luteal phase) Sus scrofa
-
2.7.11.25 epididymis lowest expression Sus scrofa
-
2.7.11.25 hypophysis
-
 Sus scrofa
-
2.7.11.25 hypothalamus
-
 Sus scrofa
-
2.7.11.25 luteal cell
-
 Sus scrofa
-
2.7.11.25 pineal gland
-
 Sus scrofa
-
2.7.11.25 testis
-
 Sus scrofa
-
2.7.11.25 uterus
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.25 ATP + ERK1/2
-
 Sus scrofa ADP + phosphorylated ERK1/2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.25 MAP3K8
-
 Sus scrofa
2.7.11.25 mitogen-activated protein kinase kinase kinase 8
-
 Sus scrofa

Expression

EC Number Organism Comment Expression
2.7.11.25 Sus scrofa after 12-24 h treatment of luteal cells with 100 ng/ml LH, isoform MAP3K8 expression is significantly upregulated up

General Information

EC Number General Information Comment Organism
2.7.11.25 physiological function isoform MAP3K8 mediates the LH-induced stimulation of progesterone synthesis through the protein kinase A/mitogen-activated protein kinase signalling pathway in porcine corpus lutem Sus scrofa