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Literature summary extracted from

  • Theron, A.; Roth, R.L.; Hoppe, H.; Parkinson, C.; van der Westhuyzen, C.W.; Stoychev, S.; Wiid, I.; Pietersen, R.D.; Baker, B.; Kenyon, C.P.
    Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform (2017), PLoS ONE, 12, e0185068 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.42 co-expressed with Mycobacterium tuberculosis glutamine synthetase in Escherichia coli BL21 lambda(DE3) cells lacking glutamine synthetase and adenylyltransferase genes Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.42 ATP + [glutamine synthetase]-L-tyrosine Mycobacterium tuberculosis
-
 diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine
-
 ?
2.7.7.42 ATP + [glutamine synthetase]-L-tyrosine Mycobacterium tuberculosis H37Rv
-
 diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.42 Mycobacterium tuberculosis P9WN27
-
-
2.7.7.42 Mycobacterium tuberculosis H37Rv P9WN27
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.42 ATP + [glutamine synthetase]-L-tyrosine
-
 Mycobacterium tuberculosis diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine
-
 ?
2.7.7.42 ATP + [glutamine synthetase]-L-tyrosine
-
 Mycobacterium tuberculosis H37Rv diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.42 adenylyltransferase
-
 Mycobacterium tuberculosis
2.7.7.42 ATASE
-
 Mycobacterium tuberculosis
2.7.7.42 GlnE
-
 Mycobacterium tuberculosis