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Literature summary extracted from

  • Yu, L.; Xu, J.; Liu, L.; Bian, X.; Liu, Y.
    Purification and catalytic properties of methylenetetrahydrofolate reductase (2011), Pharm. Biotechnol., 18, 300-303 .
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.53 S-adenosyl-L-methionine allosteric inhibitor, up to 60% decrease in activity Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.53 0.0703
-
 5,10-methylenetetrahydrofolate pH 6.8, 37°C Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.53 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.53 purification from liver Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.53 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.53 5,10-methylenetetrahydrofolate + NADPH + H+
-
 Sus scrofa 5-methyltetrahydrofolate + NADP+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.5.1.53 37
-
-
 Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.53 6.8
-
-
 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.53 NADPH
-
 Sus scrofa