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Literature summary extracted from

  • Thakur, M.; Mohan, D.; Singh, A.K.; Agarwal, A.; Gopal, B.; Muniyappa, K.
    Novel insights into ATP-stimulated cleavage of branched DNA and RNA substrates through structure-guided studies of the Holliday junction resolvase RuvX (2021), J. Mol. Biol., 433, 167014 .
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.21.10 Mg2+ required Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.21.10 additional information Mycobacterium tuberculosis the enzyme exhibits relaxed substrate specificity, cleaving a variety of branched DNA/RNA substrates. Notably, ATP hydrolysis plays a regulatory role, rendering the enzyme from a canonical Holliday junction resolvase to a DNA/RNA non-sequence specific endonuclease. The enzyme also has ATPase activity ?
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3.1.21.10 additional information Mycobacterium tuberculosis H37Rv the enzyme exhibits relaxed substrate specificity, cleaving a variety of branched DNA/RNA substrates. Notably, ATP hydrolysis plays a regulatory role, rendering the enzyme from a canonical Holliday junction resolvase to a DNA/RNA non-sequence specific endonuclease. The enzyme also has ATPase activity ?
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-

Organism

EC Number Organism UniProt Comment Textmining
3.1.21.10 Mycobacterium tuberculosis
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3.1.21.10 Mycobacterium tuberculosis H37Rv
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.21.10 additional information the enzyme exhibits relaxed substrate specificity, cleaving a variety of branched DNA/RNA substrates. Notably, ATP hydrolysis plays a regulatory role, rendering the enzyme from a canonical Holliday junction resolvase to a DNA/RNA non-sequence specific endonuclease. The enzyme also has ATPase activity Mycobacterium tuberculosis ?
-
-
3.1.21.10 additional information the enzyme exhibits relaxed substrate specificity, cleaving a variety of branched DNA/RNA substrates. Notably, ATP hydrolysis plays a regulatory role, rendering the enzyme from a canonical Holliday junction resolvase to a DNA/RNA non-sequence specific endonuclease. The enzyme also has ATPase activity Mycobacterium tuberculosis H37Rv ?
-
-

Subunits

EC Number Subunits Comment Organism
3.1.21.10 homodimer x-ray crystallography Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
3.1.21.10 HJ resolvase
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 Mycobacterium tuberculosis
3.1.21.10 Holliday junction resolvase
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 Mycobacterium tuberculosis
3.1.21.10 RuvX
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 Mycobacterium tuberculosis