EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.20 | - |
Mycobacterium tuberculosis |
2.7.1.20 | - |
Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.7.1.20 | vapor diffusion method at 20°C | Mycobacterium tuberculosis |
2.7.1.20 | vapor diffusion method at 20°C | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.20 | (1R,2S,3R,5R)-3-(6-(4-([1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol | - |
Mycobacterium tuberculosis | |
2.7.1.20 | (2R,3R,4S,5R)-2-(6-(4-(4-(1-(difluoromethyl)-1H-pyrazol-4-yl)phenyl)piperazin-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | - |
Mycobacterium tuberculosis | |
2.7.1.20 | (2R,3R,4S,5R)-2-(6-(4-([1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | - |
Mycobacterium tuberculosis | |
2.7.1.20 | (2R,3R,4S,5R)-2-(6-([1,1'-biphenyl]-4-ylethynyl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | - |
Mycobacterium tuberculosis | |
2.7.1.20 | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(3'-(morpholinomethyl)-[1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | - |
Homo sapiens | |
2.7.1.20 | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(3'-(morpholinomethyl)-[1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | - |
Mycobacterium tuberculosis | |
2.7.1.20 | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4'-(2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | - |
Mycobacterium tuberculosis | |
2.7.1.20 | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | - |
Mycobacterium tuberculosis | |
2.7.1.20 | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4-(6-(trifluoromethyl)pyridin-3-yl)phenyl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | - |
Homo sapiens | |
2.7.1.20 | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4-(6-(trifluoromethyl)pyridin-3-yl)phenyl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | - |
Mycobacterium tuberculosis | |
2.7.1.20 | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4-(6-methoxypyridin-3-yl)phenyl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | - |
Mycobacterium tuberculosis | |
2.7.1.20 | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(phenylethynyl)phenyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | - |
Mycobacterium tuberculosis | |
2.7.1.20 | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-phenylpiperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | - |
Homo sapiens | |
2.7.1.20 | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-phenylpiperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | - |
Mycobacterium tuberculosis | |
2.7.1.20 | 7-[4-([1,1'-biphenyl]-4-yl)piperazin-1-yl]-3-beta-D-ribofuranosyl-3H-imidazo[4,5-b]pyridine | - |
Mycobacterium tuberculosis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.20 | 1.71 | - |
adenosine | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.20 | ATP + adenosine | Homo sapiens | - |
ADP + AMP | - |
? | |
2.7.1.20 | ATP + adenosine | Mycobacterium tuberculosis | essential enzyme of Mycobacterium tuberculosis and forms part of the purine salvage pathway within mycobacteria | ADP + AMP | - |
? | |
2.7.1.20 | ATP + adenosine | Mycobacterium tuberculosis H37Rv | essential enzyme of Mycobacterium tuberculosis and forms part of the purine salvage pathway within mycobacteria | ADP + AMP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.20 | Homo sapiens | P55263 | - |
- |
2.7.1.20 | Mycobacterium tuberculosis | P9WID5 | - |
- |
2.7.1.20 | Mycobacterium tuberculosis H37Rv | P9WID5 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.20 | - |
Mycobacterium tuberculosis |
2.7.1.20 | - |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.20 | ATP + adenosine | - |
Mycobacterium tuberculosis | ADP + AMP | - |
? | |
2.7.1.20 | ATP + adenosine | - |
Homo sapiens | ADP + AMP | - |
? | |
2.7.1.20 | ATP + adenosine | essential enzyme of Mycobacterium tuberculosis and forms part of the purine salvage pathway within mycobacteria | Mycobacterium tuberculosis | ADP + AMP | - |
? | |
2.7.1.20 | ATP + adenosine | - |
Mycobacterium tuberculosis H37Rv | ADP + AMP | - |
? | |
2.7.1.20 | ATP + adenosine | essential enzyme of Mycobacterium tuberculosis and forms part of the purine salvage pathway within mycobacteria | Mycobacterium tuberculosis H37Rv | ADP + AMP | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.1.20 | homodimer | - |
Mycobacterium tuberculosis |
2.7.1.20 | homodimer | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.20 | 0.0000053 | - |
(2R,3R,4S,5R)-2-(6-(4-([1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
2.7.1.20 | 0.0000163 | - |
7-[4-([1,1'-biphenyl]-4-yl)piperazin-1-yl]-3-beta-D-ribofuranosyl-3H-imidazo[4,5-b]pyridine | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
2.7.1.20 | 0.0000185 | - |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4-(6-methoxypyridin-3-yl)phenyl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
2.7.1.20 | 0.0000189 | - |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4'-(2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
2.7.1.20 | 0.0000199 | - |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(phenylethynyl)phenyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
2.7.1.20 | 0.0000213 | - |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
2.7.1.20 | 0.000023 | - |
(2R,3R,4S,5R)-2-(6-(4-(4-(1-(difluoromethyl)-1H-pyrazol-4-yl)phenyl)piperazin-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
2.7.1.20 | 0.0000255 | - |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(3'-(morpholinomethyl)-[1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
2.7.1.20 | 0.0000275 | - |
(1R,2S,3R,5R)-3-(6-(4-([1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
2.7.1.20 | 0.000048 | - |
(2R,3R,4S,5R)-2-(6-([1,1'-biphenyl]-4-ylethynyl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
2.7.1.20 | 0.00012 | - |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-phenylpiperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
2.7.1.20 | 0.000326 | - |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4-(6-(trifluoromethyl)pyridin-3-yl)phenyl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
2.7.1.20 | 0.00041 | - |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(3'-(morpholinomethyl)-[1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Homo sapiens | |
2.7.1.20 | 0.0016 | - |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4-(6-(trifluoromethyl)pyridin-3-yl)phenyl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Homo sapiens | |
2.7.1.20 | 0.0051 | - |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-phenylpiperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | pH 7.5, temperature not specified in the publication | Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.20 | metabolism | essential enzyme of Mycobacterium tuberculosis and forms part of the purine salvage pathway within mycobacteria | Mycobacterium tuberculosis |