EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.301 | - |
Mycobacterium tuberculosis |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.3.1.301 | strucure to 2.1 A resolution. A CoA/malonyl-ACP-binding channel leads from the enzyme surface to the buried active-site cysteine residue, and a second hydrophobic channel leads from the active site. In the ecFabH structure, this channel is blocked by a phenylalanine residue, whereas in Microbacterium tuberculosisFabH, this residue is a threonine, which permits binding of longer acyl chains | Mycobacterium tuberculosis |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.1.301 | 76600 | - |
gel filtration | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.301 | Mycobacterium tuberculosis | P9WNG3 | - |
- |
2.3.1.301 | Mycobacterium tuberculosis H37Rv | P9WNG3 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.301 | additional information | enzyme catalyzes a Claisen-type condensation between long chain acyl-CoA substrates such as myristoyl-CoA (C14) and malonyl-ACP. No substrates: acetyl-CoA, butanoyl-CoA | Mycobacterium tuberculosis | ? | - |
- |
|
2.3.1.301 | additional information | enzyme catalyzes a Claisen-type condensation between long chain acyl-CoA substrates such as myristoyl-CoA (C14) and malonyl-ACP. No substrates: acetyl-CoA, butanoyl-CoA | Mycobacterium tuberculosis H37Rv | ? | - |
- |
|
2.3.1.301 | myristoyl-CoA + a malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.301 | myristoyl-CoA + a malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis H37Rv | 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.1.301 | dimer | 2 * 37000, SDS-PAGE | Mycobacterium tuberculosis |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.301 | FabH | - |
Mycobacterium tuberculosis |