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Literature summary extracted from

  • Scarsdale, J.; Kazanina, G.; He, X.; Reynolds, K.; Wright, H.
    Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (2001), J. Biol. Chem., 276, 20516-20522 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.301
-
Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.301 strucure to 2.1 A resolution. A CoA/malonyl-ACP-binding channel leads from the enzyme surface to the buried active-site cysteine residue, and a second hydrophobic channel leads from the active site. In the ecFabH structure, this channel is blocked by a phenylalanine residue, whereas in Microbacterium tuberculosisFabH, this residue is a threonine, which permits binding of longer acyl chains Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.301 76600
-
gel filtration Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.301 Mycobacterium tuberculosis P9WNG3
-
-
2.3.1.301 Mycobacterium tuberculosis H37Rv P9WNG3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.301 additional information enzyme catalyzes a Claisen-type condensation between long chain acyl-CoA substrates such as myristoyl-CoA (C14) and malonyl-ACP. No substrates: acetyl-CoA, butanoyl-CoA Mycobacterium tuberculosis ?
-
-
2.3.1.301 additional information enzyme catalyzes a Claisen-type condensation between long chain acyl-CoA substrates such as myristoyl-CoA (C14) and malonyl-ACP. No substrates: acetyl-CoA, butanoyl-CoA Mycobacterium tuberculosis H37Rv ?
-
-
2.3.1.301 myristoyl-CoA + a malonyl-[acyl-carrier protein]
-
Mycobacterium tuberculosis 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2
-
?
2.3.1.301 myristoyl-CoA + a malonyl-[acyl-carrier protein]
-
Mycobacterium tuberculosis H37Rv 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2
-
?

Subunits

EC Number Subunits Comment Organism
2.3.1.301 dimer 2 * 37000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.3.1.301 FabH
-
Mycobacterium tuberculosis