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Literature summary extracted from

  • Choi, K.; Kremer, L.; Besra, G.; Rock, C.
    Identification and substrate specificity of beta-ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis (2000), J. Biol. Chem., 275, 28201-28207 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.301 additional information not inhibitory: cerulenin Mycobacterium tuberculosis
2.3.1.301 thiolactomycin
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.301 decanoyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis
-
 3-oxolauroyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 decanoyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis H37Rv
-
 3-oxolauroyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 lauroyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis
-
 3-oxomyristoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 lauroyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis H37Rv
-
 3-oxomyristoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 additional information Mycobacterium tuberculosis FabH clearly prefers long-chain acyl-CoA substrates rather than acyl-ACP primers and does not utilize acetyl-CoA as a primer. No substrates: acetyl-CoA, butyryl-CoA, or isovaleryl-CoA ?
-
-
2.3.1.301 additional information Mycobacterium tuberculosis H37Rv FabH clearly prefers long-chain acyl-CoA substrates rather than acyl-ACP primers and does not utilize acetyl-CoA as a primer. No substrates: acetyl-CoA, butyryl-CoA, or isovaleryl-CoA ?
-
-
2.3.1.301 myristoyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis
-
 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 myristoyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis H37Rv
-
 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 octanoyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis
-
 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 octanoyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis H37Rv
-
 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 palmitoyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis
-
 3-oxostearoyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.301 Mycobacterium tuberculosis P9WNG3
-
-
2.3.1.301 Mycobacterium tuberculosis H37Rv P9WNG3
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.301 0.0013
-
 substrate palmitoyl-CoA, pH 7., 37°C Mycobacterium tuberculosis
2.3.1.301 0.0134
-
 substrate octanoyl-CoA, pH 7., 37°C Mycobacterium tuberculosis
2.3.1.301 0.0269
-
 substrate decanoyl-CoA, pH 7., 37°C Mycobacterium tuberculosis
2.3.1.301 0.0569
-
 substrate myristoyl-CoA, pH 7., 37°C Mycobacterium tuberculosis
2.3.1.301 0.13
-
 substrate lauroyl-CoA, pH 7., 37°C Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.301 decanoyl-CoA + malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis 3-oxolauroyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 decanoyl-CoA + malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis H37Rv 3-oxolauroyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 lauroyl-CoA + malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis 3-oxomyristoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 lauroyl-CoA + malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis H37Rv 3-oxomyristoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 additional information FabH clearly prefers long-chain acyl-CoA substrates rather than acyl-ACP primers and does not utilize acetyl-CoA as a primer. No substrates: acetyl-CoA, butyryl-CoA, or isovaleryl-CoA Mycobacterium tuberculosis ?
-
-
2.3.1.301 additional information FabH clearly prefers long-chain acyl-CoA substrates rather than acyl-ACP primers and does not utilize acetyl-CoA as a primer. No substrates: acetyl-CoA, butyryl-CoA, or isovaleryl-CoA Mycobacterium tuberculosis H37Rv ?
-
-
2.3.1.301 myristoyl-CoA + malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 myristoyl-CoA + malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis H37Rv 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 octanoyl-CoA + malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 octanoyl-CoA + malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis H37Rv 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.301 palmitoyl-CoA + malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis 3-oxostearoyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.301 FabH
-
 Mycobacterium tuberculosis
2.3.1.301 Rv0533c
-
 Mycobacterium tuberculosis