EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.53 | dihydropteroylhexaglutamate | inhibits reduction of quinonoid dihydropterins | Sus scrofa | |
1.5.1.53 | S-adenosyl-L-methionine | inhibits reduction of quinonoid dihydropterins | Sus scrofa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.53 | 0.016 | - |
NADPH | cosubstrate 5,10-methylenetetrahydrofolate, pH 7.2, 25°C | Sus scrofa | |
1.5.1.53 | 0.02 | - |
5,10-methylenetetrahydrofolate | cosubstrate NADH, pH 7.2, 25°C | Sus scrofa | |
1.5.1.53 | 0.02 | - |
5,10-methylenetetrahydrofolate | cosubstrate NADPH, pH 7.2, 25°C | Sus scrofa | |
1.5.1.53 | 0.03 | - |
dihydrobiopterin | cosubstrate NADPH, pH 7.2, 25°C | Sus scrofa | |
1.5.1.53 | 0.04 | - |
dihydrofolate | cosubstrate NADPH, pH 7.2, 25°C | Sus scrofa | |
1.5.1.53 | 0.1 | - |
NADH | cosubstrate 5,10-methylenetetrahydrofolate, pH 7.2, 25°C | Sus scrofa |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.53 | Sus scrofa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.5.1.53 | liver | - |
Sus scrofa | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.53 | 5,10-methylenetetrahydrofolate + NADH + H+ | - |
Sus scrofa | 5-methyltetrahydrofolate + NAD+ | - |
? | |
1.5.1.53 | 5,10-methylenetetrahydrofolate + NADPH + H+ | - |
Sus scrofa | 5-methyltetrahydrofolate + NADP+ | - |
? | |
1.5.1.53 | 6,7-dimethyl-7,8-dihydropterin + NADH + H+ | - |
Sus scrofa | 6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+ | - |
? | |
1.5.1.53 | dihydrobiopterin + NADPH + H+ | - |
Sus scrofa | tetrahydrobiopterin + NADP+ | - |
? | |
1.5.1.53 | dihydrofolate + NADPH + H+ | - |
Sus scrofa | tetrahydrofolate + NADP+ | - |
? | |
1.5.1.53 | additional information | under Vmax conditions, the turnover numbers for the NADPH-linked reductions of the quinonoid forms of 6,7-dimethyldihydropterin, dihydrobiopterin, and dihydrofolate are all about the same as that for the reduction of methylenetetrahydrofolate. The reduction of quinonoid dihydropterins is inhibited by S-adenosyl-L-methionine and dihydropteroylhexaglutamate | Sus scrofa | ? | - |
- |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.53 | NADH | NADPH is 6fold preferred over NADH | Sus scrofa | |
1.5.1.53 | NADPH | - |
Sus scrofa |