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Literature summary extracted from

  • Diaz-Viraque, F.; Chiribao, M.L.; Trochine, A.; Gonzalez-Herrera, F.; Castillo, C.; Liempi, A.; Kemmerling, U.; Maya, J.D.; Robello, C.
    Old yellow enzyme from Trypanosoma cruzi exhibits in vivo prostaglandin F2alpha synthase activity and has a key role in parasite infection and drug susceptibility (2018), Front. Immunol., 9, 456 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.1.1.188 medicine mice infected with PGFS overexpressing parasites show an early parasitemia peak and higher heart muscle parasitic load Trypanosoma cruzi

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.188 expression in Escherichia coli Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.188 cytosol
-
 Trypanosoma cruzi 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.188 Trypanosoma cruzi V5BT91
-
-
1.1.1.188 Trypanosoma cruzi Dm28c V5BT91
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.188 amastigote
-
 Trypanosoma cruzi
-
1.1.1.188 epimastigote
-
 Trypanosoma cruzi
-

Synonyms

EC Number Synonyms Comment Organism
1.1.1.188 TCDM_00059
-
 Trypanosoma cruzi

General Information

EC Number General Information Comment Organism
1.1.1.188 physiological function PGFS overexpressing parasites are less able to complete the infective cycle in cell culture infections and increase cardiac tissue parasitic load in infected mice. Parasites overexpressing the enzyme increase PGF2alpha synthesis from arachidonic acid and display increased susceptibility to benznidazole and nifurtimox but increased resistance to hydrogen peroxide Trypanosoma cruzi