Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tiwari, S.; Barh, D.; Imchen, M.; Rao, E.; Kumavath, R.K.; Seenivasan, S.P.; Jaiswal, A.K.; Jamal, S.B.; Kumar, V.; Ghosh, P.; Azevedo, V.
    Acetate kinase (AcK) is essential for microbial growth and betel-derived compounds potentially target AcK, PhoP and MDR proteins in M. tuberculosis, V. cholerae and pathogenic E. coli an in silico and in vitro study (2018), Curr. Top. Med. Chem., 18, 2731-2740 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.2.1 expressed in Escherichia coli DH5alpha cells Mycobacterium tuberculosis
2.7.2.1 expressed in Escherichia coli DH5alpha cells Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.2.1 6-oxopiperidine-3-carboxylic acid 82.6% inhibition at 70 mM Escherichia coli
2.7.2.1 6-oxopiperidine-3-carboxylic acid
-
 Mycobacterium tuberculosis
2.7.2.1 chlorogenic acid 58.74% inhibition at 70 mM Escherichia coli
2.7.2.1 chlorogenic acid
-
 Mycobacterium tuberculosis
2.7.2.1 eugenyl acetate 66.52% inhibition at 70 mM Escherichia coli
2.7.2.1 additional information not inhibited by eugenyl acetate and pinoresinol Mycobacterium tuberculosis
2.7.2.1 pinoresinol 82.6% inhibition at 70 mM Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.2.1 ATP + acetate Mycobacterium tuberculosis
-
 ADP + acetyl phosphate
-
 ?
2.7.2.1 ATP + acetate Escherichia coli
-
 ADP + acetyl phosphate
-
 ?
2.7.2.1 ATP + acetate Mycobacterium tuberculosis H37Rv
-
 ADP + acetyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.2.1 Escherichia coli P0A6A5
-
-
2.7.2.1 Mycobacterium tuberculosis P9WQH1
-
-
2.7.2.1 Mycobacterium tuberculosis H37Rv P9WQH1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.1 ATP + acetate
-
 Mycobacterium tuberculosis ADP + acetyl phosphate
-
 ?
2.7.2.1 ATP + acetate
-
 Escherichia coli ADP + acetyl phosphate
-
 ?
2.7.2.1 ATP + acetate
-
 Mycobacterium tuberculosis H37Rv ADP + acetyl phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.2.1 ACK
-
 Mycobacterium tuberculosis
2.7.2.1 ACK
-
 Escherichia coli