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Literature summary extracted from

  • Wang, P.; Zheng, D.; Peng, W.; Wang, Y.; Wang, X.; Xiong, W.; Liang, R.
    Characterization of 17beta-hydroxysteroid dehydrogenase and regulators involved in estrogen degradation in Pseudomonas putida SJTE-1 (2019), Appl. Microbiol. Biotechnol., 103, 2413-2425 .
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.62 0.068
-
 17beta-estradiol pH and temperature not specified in the publication Pseudomonas putida

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.62 17beta-estradiol + NAD+ Pseudomonas putida
-
 estrone + NADH + H+
-
 ?
1.1.1.62 17beta-estradiol + NAD+ Pseudomonas putida SJTE-1
-
 estrone + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Pseudomonas putida
-
-
-
1.1.1.62 Pseudomonas putida SJTE-1
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 17beta-estradiol + NAD+
-
 Pseudomonas putida estrone + NADH + H+
-
 ?
1.1.1.62 17beta-estradiol + NAD+ high efficiency, over 98% of 17beta-estradiol was oxidized into estrone in 5 min Pseudomonas putida estrone + NADH + H+
-
 ?
1.1.1.62 17beta-estradiol + NAD+
-
 Pseudomonas putida SJTE-1 estrone + NADH + H+
-
 ?
1.1.1.62 17beta-estradiol + NAD+ high efficiency, over 98% of 17beta-estradiol was oxidized into estrone in 5 min Pseudomonas putida SJTE-1 estrone + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.62 17beta-HSD
-
 Pseudomonas putida
1.1.1.62 17beta-hydroxysteroid dehydrogenase
-
 Pseudomonas putida

Expression

EC Number Organism Comment Expression
1.1.1.62 Pseudomonas putida OxyR represses the expression of 17beta-hsd by its specific binding to the conserved motif of GATA-N9-TATC down
1.1.1.62 Pseudomonas putida CrgA activates the expression of 17beta-hsd through its binding to the motif of T-N11-A up
1.1.1.62 Pseudomonas putida induced by 17beta-estradiol up