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Literature summary extracted from

  • Singh, V.; Donini, S.; Pacitto, A.; Sala, C.; Hartkoorn, R.; Dhar, N.; Keri, G.; Ascher, D.; Mondesert, G.; Vocat, A.; Lupien, A.; Sommer, R.; Vermet, H.; Lagrange, S.; Buechler, J.; Warner, D.; McKinney, J.; Pato, J.; Cole, S.; Blundell, T.; Rizzi, M.
    The inosine monophosphate dehydrogenase, GuaB2, is a vulnerable new bactericidal drug target for tuberculosis (2017), ACS Infect. Dis., 3, 5-17 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.205 hanging drop vapor diffusion method, using 100 mM sodium acetate, pH 5.5, 200 mM calcium chloride, and 8-14% (v/v) isopropanol Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.205 Y487C the mutant is not inhibited by VCC234718 Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 cyclohexyl[4-(isoquinoline-5-sulfonyl)piperazin-1-yl]methanone uncompetitive inhibition with respect to IMP and NAD+ Mycobacterium tuberculosis
1.1.1.205 VCC234718 uncompetitive inhibition with respect to IMP and NAD+ Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.205 IMP + NAD+ + H2O Mycobacterium tuberculosis
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Mycobacterium tuberculosis H37Rv
-
 XMP + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Mycobacterium tuberculosis
-
-
-
1.1.1.205 Mycobacterium tuberculosis H37Rv
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.205
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 IMP + NAD+ + H2O
-
 Mycobacterium tuberculosis XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Mycobacterium tuberculosis H37Rv XMP + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.205 guaB2
-
 Mycobacterium tuberculosis
1.1.1.205 IMPDH
-
 Mycobacterium tuberculosis
1.1.1.205 inosine monophosphate dehydrogenase
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.205 NAD+
-
 Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.205 0.0001
-
 cyclohexyl[4-(isoquinoline-5-sulfonyl)piperazin-1-yl]methanone pH and temperature not specified in the publication Mycobacterium tuberculosis
1.1.1.205 0.0001
-
 VCC234718 pH and temperature not specified in the publication Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
1.1.1.205 malfunction enzyme depletion is bactericidal in vitro and ex vivo Mycobacterium tuberculosis
1.1.1.205 physiological function the enzyme is essential for Mycobacterium tuberculosis to establish an infection in mice Mycobacterium tuberculosis