EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.4.9 | expression in Escherichia coli | Mycobacterium tuberculosis |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.7.4.9 | sitting-drop vapor-diffusion method at 20°C | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.4.9 | 1-(1-benzylpiperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-(1-[[4-(3-chlorophenoxy)quinolin-2-yl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-(1-[[4-(dimethylamino)phenyl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[1-(cyclohexylmethyl)piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[1-[(1-benzofuran-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[1-[(4-methoxyphenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[1-[(7-chloro-4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[1-[(furan-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[1-[(furan-3-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[1-[(isoquinolin-1-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[1-[(isoquinolin-3-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[1-[(isoquinolin-4-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 4-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]benzoic acid | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 4-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]benzonitrile | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-(1-[[4-(1H-tetrazol-5-yl)phenyl]methyl]piperidin-4-yl)pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-(2-[methyl[(3-phenoxyphenyl)methyl]amino]ethyl)pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[(3S)-1-[(3-phenoxyphenyl)methyl]piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-(2-phenylethyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-(3-phenoxybenzoyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-(4-phenoxybenzoyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(3-methylphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(3-phenoxyphenyl)methyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(3-phenoxyphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(4-methylphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(4-phenoxyphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(naphthalen-1-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(naphthalen-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(pyridin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(pyridin-3-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(pyridin-4-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(quinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(quinolin-3-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[(quinolin-4-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[2-(3-phenoxyphenyl)ethyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[2-(3-phenoxyphenyl)ethyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-methyl-1-[1-[3-(3-phenoxyphenyl)propyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]pyridine-2-carboxylic acid | - |
Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.4.9 | Mycobacterium tuberculosis | A5U7S1 | - |
- |
2.7.4.9 | Mycobacterium tuberculosis | P9WKE1 | - |
- |
2.7.4.9 | Mycobacterium tuberculosis H37Rv | P9WKE1 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.4.9 | - |
Mycobacterium tuberculosis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.4.9 | ATP + dTMP | - |
Mycobacterium tuberculosis | ADP + dTDP | - |
? | |
2.7.4.9 | ATP + dTMP | - |
Mycobacterium tuberculosis H37Rv | ADP + dTDP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.4.9 | thymidylate kinase | - |
Mycobacterium tuberculosis |
2.7.4.9 | TMPK | - |
Mycobacterium tuberculosis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.4.9 | 0.00095 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-(1-[[4-(3-chlorophenoxy)quinolin-2-yl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.00096 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-(1-[[4-(3-chlorophenoxy)quinolin-2-yl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.0011 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.0018 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-[1-[(7-chloro-4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.0061 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(3-phenoxyphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.0071 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.009 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(quinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.01 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[(3S)-1-[(3-phenoxyphenyl)methyl]piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.011 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[2-(3-phenoxyphenyl)ethyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.017 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(quinolin-3-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.02 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(naphthalen-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.023 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-[1-[(1-benzofuran-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.025 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(quinolin-4-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.025 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-[1-[(isoquinolin-4-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.026 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-[1-[(isoquinolin-3-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.027 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-[1-[(isoquinolin-1-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.029 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(4-phenoxyphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.03251 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.035 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 4-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]benzonitrile | |
2.7.4.9 | 0.038 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(naphthalen-1-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.04 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.049 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(pyridin-4-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.06045 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.072 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(3-methylphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.075 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(pyridin-3-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.098 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(pyridin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.113 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-[1-[(4-methoxyphenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.114 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-[1-[(furan-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.129 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-(2-phenylethyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.138 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-(1-benzylpiperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.141 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 4-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]benzoic acid | |
2.7.4.9 | 0.142 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-(1-[[4-(1H-tetrazol-5-yl)phenyl]methyl]piperidin-4-yl)pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.143 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]pyridine-2-carboxylic acid | |
2.7.4.9 | 0.168 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(4-methylphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.235 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-(3-phenoxybenzoyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.254 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-[1-[(furan-3-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.328 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-(1-[[4-(dimethylamino)phenyl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.353 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-(4-phenoxybenzoyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.72 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-(2-[methyl[(3-phenoxyphenyl)methyl]amino]ethyl)pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 0.944 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[(3-phenoxyphenyl)methyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 1.115 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 1-[1-(cyclohexylmethyl)piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 1.14 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[3-(3-phenoxyphenyl)propyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione | |
2.7.4.9 | 1.91 | - |
pH 7.4, temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-1-[1-[2-(3-phenoxyphenyl)ethyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.4.9 | drug target | the enzyme is indispensable for bacterial DNA biosynthesis and has been pursued for the development of new antibacterial agents including against Mycobacterium tuberculosis | Mycobacterium tuberculosis |
2.7.4.9 | physiological function | the enzyme is indispensable for bacterial DNA biosynthesis | Mycobacterium tuberculosis |