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Literature summary extracted from
- Heme A synthesis and CcO activity are essential for Trypanosoma cruzi infectivity and replication (2017), Biochem. J., 474, 2315-2332 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.17.99.9 | expression of TcCOX15.HIS-GFP in yeast | Trypanosoma cruzi |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.17.99.9 | H129A | overexpression of the non-functional TcCox15 mutants causes a negative effect over heme A synthesis, affecting the function of the CcO complex and proliferation of epimastigotes | Trypanosoma cruzi |
| 1.17.99.9 | H206A | overexpression of the non-functional TcCox15 mutants causes a negative effect over heme A synthesis, affecting the function of the CcO complex and proliferation of epimastigotes | Trypanosoma cruzi |
| 1.17.99.9 | H307A | overexpression of the non-functional TcCox15 mutants causes a negative effect over heme A synthesis, affecting the function of the CcO complex and proliferation of epimastigotes | Trypanosoma cruzi |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.17.99.9 | mitochondrion | - |
Trypanosoma cruzi | 5739 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.17.99.9 | Trypanosoma cruzi | V5BC58 | - |
- |
| 1.17.99.9 | Trypanosoma cruzi Dm28c | V5BC58 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.17.99.9 | amastigote | the replicative life stages (epimastigotes and amastigotes) show higher TcCox15 levels than the infective and non-replicative stage (trypomastigotes). Two times higher level in epimastigotes than in amastigotes and five times higher level than in trypomastigotes | Trypanosoma cruzi | - |
| 1.17.99.9 | epimastigote | the replicative life stages (epimastigotes and amastigotes) show higher TcCox15 levels than the infective and non-replicative stage (trypomastigotes). Two times higher level in epimastigotes than in amastigotes and five times higher level than in trypomastigotes | Trypanosoma cruzi | - |
| 1.17.99.9 | trypomastigote | the replicative life stages (epimastigotes and amastigotes) show higher TcCox15 levels than the infective and non-replicative stage (trypomastigotes). Two times higher level in epimastigotes than in amastigotes and five times higher level than in trypomastigotes | Trypanosoma cruzi | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.17.99.9 | HAS | - |
Trypanosoma cruzi |
| 1.17.99.9 | TcCox15 | - |
Trypanosoma cruzi |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.17.99.9 | malfunction | overexpression of a non-functional mutant causes a reduction in heme A content. This hindrance in the heme A synthesis provokes a reduction on CcO activity and, in consequence, an impairment on Trypanosoma cruzi survival, proliferation and infectivity | Trypanosoma cruzi |
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Release 2023.1 (January 2023)
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