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Literature summary extracted from

  • Iftikhar, H.; Batool, S.; Deep, A.; Narasimhan, B.; Sharma, P.; Malhotra, M.
    In silico analysis of the inhibitory activities of GABA derivatives on 4-aminobutyrate transaminase (2017), Arab. J. Chem., 10, S1267-S1275 .
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-(4-ethylphenyl)butanamide
-
 Homo sapiens
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-(4-ethylphenyl)butanamide
-
 Sus scrofa
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorophenyl)butanamide
-
 Homo sapiens
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorophenyl)butanamide
-
 Sus scrofa
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-(4-iodophenyl)butanamide
-
 Homo sapiens
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-(4-iodophenyl)butanamide
-
 Sus scrofa
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-(4-methoxyphenyl)butanamide
-
 Homo sapiens
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-(4-methoxyphenyl)butanamide
-
 Sus scrofa
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-(4-nitrophenyl)butanamide
-
 Homo sapiens
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-(4-nitrophenyl)butanamide
-
 Sus scrofa
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-p-tolylbutanamide
-
 Homo sapiens
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-p-tolylbutanamide
-
 Sus scrofa
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-phenylbutanamide
-
 Homo sapiens
2.6.1.19 4-(1,3-dioxoisoindolin-2-yl)-N-phenylbutanamide
-
 Sus scrofa
2.6.1.19 additional information a series of gamma-aminobutyric acid (GABA) derivatives obtained from 4-(1,3-dioxoisoindolin-2-yl)butanoic acid are synthesized and analyzed as inhibitory ligands docking against human ABAT as well as pig ABAT receptors. Active site docking study, overview Homo sapiens
2.6.1.19 additional information a series of gamma-aminobutyric acid (GABA) derivatives obtained from 4-(1,3-dioxoisoindolin-2-yl)butanoic acid are synthesized and analyzed as inhibitory ligands docking against human ABAT as well as pig ABAT receptors. Active site docking study, overview Sus scrofa
2.6.1.19 N-(2,4-dichlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Homo sapiens
2.6.1.19 N-(2,4-dichlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Sus scrofa
2.6.1.19 N-(2,4-difluorophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Homo sapiens
2.6.1.19 N-(2,4-difluorophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Sus scrofa
2.6.1.19 N-(4-bromophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Homo sapiens
2.6.1.19 N-(4-bromophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Sus scrofa
2.6.1.19 N-(4-chloro-2-iodophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Homo sapiens
2.6.1.19 N-(4-chloro-2-iodophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Sus scrofa
2.6.1.19 N-(4-chloro-2-methylphenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Homo sapiens
2.6.1.19 N-(4-chloro-2-methylphenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Sus scrofa
2.6.1.19 N-(4-chlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Homo sapiens
2.6.1.19 N-(4-chlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.19 mitochondrion
-
 Sus scrofa 5739
-
2.6.1.19 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate Sus scrofa
-
 succinate semialdehyde + L-glutamate
-
 ?
2.6.1.19 4-aminobutanoate + 2-oxoglutarate Homo sapiens
-
 succinate semialdehyde + L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Homo sapiens P80404
-
-
2.6.1.19 Sus scrofa P80147
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Sus scrofa succinate semialdehyde + L-glutamate
-
 ?
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Homo sapiens succinate semialdehyde + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.19 4-aminobutyrate transaminase
-
 Sus scrofa
2.6.1.19 4-aminobutyrate transaminase
-
 Homo sapiens
2.6.1.19 ABAT
-
 Sus scrofa
2.6.1.19 ABAT
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.19 pyridoxal 5'-phosphate
-
 Sus scrofa
2.6.1.19 pyridoxal 5'-phosphate
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.6.1.19 additional information homology structure modeling using pig ABAT as template (PDB ID 6B6G) Sus scrofa
2.6.1.19 additional information homology structure modeling using pig ABAT as template (PDB ID 6B6G) Homo sapiens