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Literature summary extracted from

  • Liang, S.C.; Ge, G.B.; Xia, Y.L.; Pei-Pei, D.; Ping, W.; Qi, X.Y.; Cai-Xia, T.; Ling, Y.
    Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites (2017), Xenobiotica, 47, 498-504 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.6 8-O-methyldaphnetin 0.1 mM, about 20% residual activity. 8-O-methyldaphnetin has no effect on Km but decreases Vmax Homo sapiens
2.1.1.6 daphnetin 0.1 mM, about 10% residual activity Homo sapiens
2.1.1.6 entacapone 0.001 mM, about 10% residual activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.6 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Homo sapiens P21964
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 S-adenosyl-L-methionine + dopamine
-
 Homo sapiens S-adenosyl-L-homocysteine + 3-O-methyldopamine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.6 0.000037
-
 daphnetin pH 7.4, 37°C Homo sapiens
2.1.1.6 0.025
-
 8-O-methyldaphnetin pH 7.4, 37°C Homo sapiens