EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.1.103 | E8A | mutation of NMT2 isoform 2, loss of activity | Arabidopsis thaliana |
2.1.1.103 | K13A | mutation of NMT2 isoform 2, loss of activity | Arabidopsis thaliana |
2.1.1.103 | R9A | mutation of NMT2 isoform 2, loss of activity | Arabidopsis thaliana |
2.1.1.103 | W16A | mutation of NMT2 isoform 2, loss of activity | Arabidopsis thaliana |
2.1.1.103 | Y15A | mutation of NMT2 isoform 2, loss of activity | Arabidopsis thaliana |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.103 | Arabidopsis thaliana | Q944H0 | isoform NMT2 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.103 | flower | expression of NMT2 isoform 2 | Arabidopsis thaliana | - |
2.1.1.103 | flower bud | expression of NMT2 isoform 2 | Arabidopsis thaliana | - |
2.1.1.103 | leaf | rosette or cauline leaf, expression of NMT2 isoform 1 | Arabidopsis thaliana | - |
2.1.1.103 | seedling | young seedling, expression of NMT2 isoform 1 | Arabidopsis thaliana | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.103 | ethanolamine phosphate + S-adenosyl-L-methionine | - |
Arabidopsis thaliana | N-methylethanolamine phosphate + S-adenosyl-L-homocysteine | - |
? | |
2.1.1.103 | additional information | the two NMT2 isoforms have the in vitro capacity to catalyze the triple methylation of phosphoethanolamine to produce choline phosphate, but with different efficiencies | Arabidopsis thaliana | ? | - |
- |
|
2.1.1.103 | N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine | - |
Arabidopsis thaliana | choline phosphate + S-adenosyl-L-homocysteine | - |
? | |
2.1.1.103 | N-methylethanolamine phosphate + S-adenosyl-L-methionine | - |
Arabidopsis thaliana | N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.103 | NMT2 | - |
Arabidopsis thaliana |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.103 | physiological function | the isoforms NMT1/NMT3 double knock-out mutant is viable. This is enabled by residual phosphoethanolamine N-methyltransferase activity through isoform NMT2. The triple NMT1/NMT2/NMT3 knock-out mutant cannot synthesize phosphatidylcholine from phosphoethanolamine and is lethal. Through alternative use of its promoter, NMT2 encodes two phosphoethanolamine N-methyltransferase variants, which greatly differ in their ability to perform the initial phosphobase methylation of phosphoethanolamine | Arabidopsis thaliana |