EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.2.6 | amikacin + H2O | Klebsiella pneumoniae | - |
? | - |
? | |
3.5.2.6 | imipenem + H2O | Klebsiella pneumoniae | - |
(5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.2.6 | Klebsiella pneumoniae | C7C422 | gene blaNDM-1; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012 | - |
3.5.2.6 | Klebsiella pneumoniae | Q2PUH3 | gene blaCTX-M-15; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012 | - |
3.5.2.6 | Klebsiella pneumoniae | Q48434 | gene blaCMY-2; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012 | - |
3.5.2.6 | Klebsiella pneumoniae | Q4LDF1 | gene blaIMP-4; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012 | - |
3.5.2.6 | Klebsiella pneumoniae | Q93LQ9 | gene blaKPC-2; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.2.6 | amikacin + H2O | - |
Klebsiella pneumoniae | ? | - |
? | |
3.5.2.6 | imipenem + H2O | - |
Klebsiella pneumoniae | (5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
3.5.2.6 | additional information | in vitro activity of 13 antimicrobial agents against 19 multidrug-resistant Klebsiella pneumoniae amikacin resistance isolates, overview | Klebsiella pneumoniae | ? | - |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.2.6 | blaCMY-2 | - |
Klebsiella pneumoniae |
3.5.2.6 | blaCTX-M-15 | - |
Klebsiella pneumoniae |
3.5.2.6 | blaIMP-4 | - |
Klebsiella pneumoniae |
3.5.2.6 | blaKPC-2 | - |
Klebsiella pneumoniae |
3.5.2.6 | blaNDM-1 | - |
Klebsiella pneumoniae |
3.5.2.6 | carbapenemase | - |
Klebsiella pneumoniae |
3.5.2.6 | metallo-beta-lactamase type 2 | UniProt | Klebsiella pneumoniae |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.5.2.6 | additional information | close to 80% of blaTEM-1 and blaSHV-12 are linked to IS26 while 90% or more of blaCTX-Ms and blaCMYs are linked to ISEcp1. ISAba125 is located upstream of blaNDM-1 and some blaCMY-2 genes. In addition, seven transconjugants are available for further analysis, and armA, qnrS1, acc(6')-Ib-cr, blaCTX-M-15, blaTEM-1, and blaNDM-1 are cotransferred. The dissemination of 16S rRNA methylase genes and the prevalence of selected elements implicated in evolution of antibiotics resistance determinants in collection of clinical Klebsiella pneumoniae in China, overview | Klebsiella pneumoniae |
3.5.2.6 | physiological function | 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) clinical isolates studied, 19 isolates exhibit high level resistance to amikacin mediated by the production of the 16S rRNA methylase. CTX-M genes were found in all of the isolates. Among these armA- or rmtB/CTX-M-producing Klebsiella pneumoniae isolates, 31.6% carry the carbapenemase genes (blaKPC-2 [26.3%], blaIMP-4 [10.5%], and blaNDM-1 [5.3%]), which made them resistant to imipenem | Klebsiella pneumoniae |