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Literature summary extracted from

  • Badawy, A.A.
    Hypothesis Metabolic targeting of 5-aminolevulinate synthase by tryptophan and inhibitors of heme utilisation by tryptophan 2,3-dioxygenase as potential therapies of acute hepatic porphyrias (2019), Med. Hypotheses, 131, 109314 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.37 carbamazepine
-
 Rattus norvegicus
2.3.1.37 estrogen
-
 Rattus norvegicus
2.3.1.37 ethanol
-
 Rattus norvegicus
2.3.1.37 ethinylestradiol
-
 Rattus norvegicus
2.3.1.37 norethandrolone
-
 Rattus norvegicus
2.3.1.37 Norethindrone
-
 Rattus norvegicus
2.3.1.37 Phenobarbitone
-
 Rattus norvegicus
2.3.1.37 Phenylbutazone
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.37 acetate
-
 Rattus norvegicus
2.3.1.37 adrenaline
-
 Rattus norvegicus
2.3.1.37 allopurinol
-
 Rattus norvegicus
2.3.1.37 aspirin
-
 Rattus norvegicus
2.3.1.37 Benserazide
-
 Rattus norvegicus
2.3.1.37 chlorpromazine
-
 Rattus norvegicus
2.3.1.37 estradiol
-
 Rattus norvegicus
2.3.1.37 estrogen
-
 Rattus norvegicus
2.3.1.37 fluoxetine
-
 Rattus norvegicus
2.3.1.37 heme
-
 Rattus norvegicus
2.3.1.37 lithium
-
 Rattus norvegicus
2.3.1.37 morphine
-
 Rattus norvegicus
2.3.1.37 naloxone
-
 Rattus norvegicus
2.3.1.37 noradrenaline
-
 Rattus norvegicus
2.3.1.37 paroxetine
-
 Rattus norvegicus
2.3.1.37 progesterone
-
 Rattus norvegicus
2.3.1.37 progestogen
-
 Rattus norvegicus
2.3.1.37 propranolol
-
 Rattus norvegicus
2.3.1.37 tryptophan
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.37 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine Rattus norvegicus
-
 5-aminolevulinate + CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.37 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Rattus norvegicus 5-aminolevulinate + CoA + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.37 5-ALA synthase
-
 Rattus norvegicus
2.3.1.37 5-ALAS
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
2.3.1.37 Rattus norvegicus fasting (starvation) induces enzyme activity. Griseofulvin induces enzyme mRNA expression after 2 days of treatment up

General Information

EC Number General Information Comment Organism
2.3.1.37 metabolism rate-limiting enzyme of heme biosynthesis Rattus norvegicus