Literature summary extracted from

Kelly, S.D.; Clarke, B.R.; Ovchinnikova, O.G.; Sweeney, R.P.; Williamson, M.L.; Lowary, T.L.; Whitfield, C.
Klebsiella pneumoniae O1 and O2ac antigens provide prototypes for an unusual strategy for polysaccharide antigen diversification (2019), J. Biol. Chem., 294, 10863-10876 .

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.4.1.44	expression in Escherichia coli	Klebsiella pneumoniae

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.4.1.44	UDP-alpha-D-galactose + lipopolysaccharide	Klebsiella pneumoniae	-	UDP + 3-alpha-D-galactosyl-[lipopolysaccharide glucose]	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.44	Klebsiella pneumoniae	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.1.44	UDP-alpha-D-galactose + lipopolysaccharide	-	Klebsiella pneumoniae	UDP + 3-alpha-D-galactosyl-[lipopolysaccharide glucose]	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.4.1.44	Wbby	-	Klebsiella pneumoniae

General Information

EC Number	General Information	Comment	Organism
2.4.1.44	physiological function	WbbY possesses two glycosyltransferase catalytic sites solely responsible for O1 antigen polymerization and forming a complex with the O2a glycosyltransferase WbbM. The C-terminal WbbY domain is a UDP-galactopyranoside-dependent GT-A galactosyltransferase adding beta-(1-3)-linked D-galalctopyranoside, whereas the WbbY N-terminus includes a GT-B enzyme adding alpha-(1-3)-linked D-galactofuranoside. These activities build the O1 antigen on a terminal galactopyranoside in the O2a domain	Klebsiella pneumoniae

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Release 2023.1 (January 2023)