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Literature summary extracted from

  • White, D.S.; Choy, C.J.; Moural, T.W.; Martin, S.E.; Wang, J.; Gargaro, S.; Kang, C.; Berkman, C.E.
    Bis(benzoyl) phosphate inactivators of beta-lactamase C from Mtb (2019), Bioorg. Med. Chem. Lett., 29, 2116-2118 .
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.2.6 drug development enzyme BlaC is a rational enzyme target for therapeutic agents in treatment of tuberculosis caused by Mycobacterium tuberculosis Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 bis(3,4-dichlorobenzoyl) phosphate
-
 Mycobacterium tuberculosis
3.5.2.6 bis(4-chlorobenzoyl) phosphate
-
 Mycobacterium tuberculosis
3.5.2.6 bis(4-cyanobenzoyl) phosphate
-
 Mycobacterium tuberculosis
3.5.2.6 bis(4-fluorobenzoyl) phosphate
-
 Mycobacterium tuberculosis
3.5.2.6 bis(4-methoxybenzoyl)
-
 Mycobacterium tuberculosis
3.5.2.6 bis(4-methylbenzoyl) phosphate
-
 Mycobacterium tuberculosis
3.5.2.6 bis(4-nitrobenzoyl) phosphate
-
 Mycobacterium tuberculosis
3.5.2.6 bis[4-(trifluoromethyl)benzoyl] phosphate
-
 Mycobacterium tuberculosis
3.5.2.6 di([1,1'-biphenyl]-4-carbonyl) phosphate
-
 Mycobacterium tuberculosis
3.5.2.6 dibenzoyl phosphate
-
 Mycobacterium tuberculosis
3.5.2.6 additional information synthesis and structure-activity-relationship data for the first-generation library of bis(benzoyl)phosphates as enzyme inhibitors, overview. Phosphorylated Ser70 in BlaC following inactivation by dibenzoyl phosphate Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.2.6 cell surface the class A beta-lactamase BlaC is a cell surface expressed serine hydrolase Mycobacterium tuberculosis 9986
-

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Mycobacterium tuberculosis P9WKD3
-
-
3.5.2.6 Mycobacterium tuberculosis ATCC 25618 P9WKD3
-
-
3.5.2.6 Mycobacterium tuberculosis H37Rv P9WKD3
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.5.2.6 phosphoprotein phosphorylated Ser70 in BlaC following inactivation by dibenzoyl phosphate Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 BlaC
-
 Mycobacterium tuberculosis
3.5.2.6 class A beta-lactamase
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
3.5.2.6 malfunction inactivation of the cell surface-expressed serine hydrolase and class A beta-lactamase BlaC in Mycobacterium tuberculosis (Mtb) causes increased susceptibility to beta-lactam antibiotics Mycobacterium tuberculosis