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Literature summary extracted from

  • Silvers, M.A.; Pakhomova, S.; Neau, D.B.; Silvers, W.C.; Anzalone, N.; Taylor, C.M.; Waldrop, G.L.
    Crystal structure of carboxyltransferase from Staphylococcus aureus bound to the antibacterial agent moiramide B (2016), Biochemistry, 55, 4666-4674 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.3.15
-
 Staphylococcus aureus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.3.15 moiramide B bound to carboxyltransferase, sitting drop vapor diffusion method, using 0.1 M MES (pH 5.0) and 1.6 M NH4SO4 Staphylococcus aureus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.3.15 (3S)-beta-phenylalanine-L-valine-(4S)-methyl-2,5-pyrrolidinedione
-
 Staphylococcus aureus
2.1.3.15 (3S)-L-valine-(4S)-methyl-2,5-pyrrolidinedione
-
 Staphylococcus aureus
2.1.3.15 (3S)-methyl-2,5-pyrrolidinedione
-
 Staphylococcus aureus
2.1.3.15 moiramide B
-
 Staphylococcus aureus
2.1.3.15 succinimide
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.3.15 [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA Staphylococcus aureus
-
 [biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
-
 r
2.1.3.15 [biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA Staphylococcus aureus
-
 [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.15 Staphylococcus aureus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.3.15 nickel affinity column chromatography and gel filtration Staphylococcus aureus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.15 [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
-
 Staphylococcus aureus [biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
-
 r
2.1.3.15 [biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
-
 Staphylococcus aureus [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.1.3.15 ACC
-
 Staphylococcus aureus
2.1.3.15 acetyl-CoA carboxylase
-
 Staphylococcus aureus
2.1.3.15 carboxyltransferase component of acetyl-CoA carboxylase Staphylococcus aureus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.3.15 0.000005
-
 moiramide B at pH 8.0, temperature not specified in the publication Staphylococcus aureus