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Literature summary extracted from
- The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis (2002), Tuberculosis, 82, 149-160 .
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.3.1.294 | additional information | non-ionic detergents such as n-octyl-beta-D-glucopyranoside have no positive effect on enzyme activity | Mycobacterium tuberculosis |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 2.3.1.293 | expressed in Mycobacterium smegmatis | Mycobacterium tuberculosis |
| 2.3.1.294 | expressed in Mycobacterium smegmatis | Mycobacterium tuberculosis |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.3.1.293 | thiolactomycin | - |
Mycobacterium tuberculosis |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.3.1.293 | an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis | C16-C26 | an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | - |
? | |
| 2.3.1.293 | an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis H37Rv | C16-C26 | an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | - |
? | |
| 2.3.1.294 | an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis | C38-C42 | an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | - |
? | |
| 2.3.1.294 | an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis H37Rv | C38-C42 | an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.3.1.293 | Mycobacterium tuberculosis | - |
- |
- |
| 2.3.1.293 | Mycobacterium tuberculosis H37Rv | - |
- |
- |
| 2.3.1.294 | Mycobacterium tuberculosis | - |
- |
- |
| 2.3.1.294 | Mycobacterium tuberculosis H37Rv | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.3.1.293 | an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] | C16-C26 | Mycobacterium tuberculosis | an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | - |
? | |
| 2.3.1.293 | an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] | C16-C26 | Mycobacterium tuberculosis H37Rv | an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | - |
? | |
| 2.3.1.293 | palmitoyl-CoA + malonyl-[acyl-carrier protein AcpM] | - |
Mycobacterium tuberculosis | ? | - |
? | |
| 2.3.1.293 | palmitoyl-CoA + malonyl-[acyl-carrier protein AcpM] | - |
Mycobacterium tuberculosis H37Rv | ? | - |
? | |
| 2.3.1.294 | an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] | C38-C42 | Mycobacterium tuberculosis | an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | - |
? | |
| 2.3.1.294 | an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] | C38-C42 | Mycobacterium tuberculosis H37Rv | an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | - |
? | |
| 2.3.1.294 | palmitoyl-CoA + malonyl-[acyl-carrier protein AcpM] | - |
Mycobacterium tuberculosis | ? | - |
? | |
| 2.3.1.294 | palmitoyl-CoA + malonyl-[acyl-carrier protein AcpM] | - |
Mycobacterium tuberculosis H37Rv | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 2.3.1.293 | ? | x * 45000, SDS-PAGE | Mycobacterium tuberculosis |
| 2.3.1.293 | ? | x * 43300, calculated from amino acid sequence | Mycobacterium tuberculosis |
| 2.3.1.294 | ? | x * 46400, calculated from amino acid sequence | Mycobacterium tuberculosis |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.3.1.293 | beta-ketoacylacyl synthase | - |
Mycobacterium tuberculosis |
| 2.3.1.293 | KasA | - |
Mycobacterium tuberculosis |
| 2.3.1.294 | beta-ketoacylacyl synthase | - |
Mycobacterium tuberculosis |
| 2.3.1.294 | KasB | - |
Mycobacterium tuberculosis |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 2.3.1.293 | 8.5 | - |
- |
Mycobacterium tuberculosis |
| 2.3.1.294 | 8.5 | - |
- |
Mycobacterium tuberculosis |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.3.1.293 | metabolism | when KasB is coexpressed with enzyme KasA, it appears to be capable of facilitating the production of lipids of the length of full meromycolic acids. KasB therefore may accept primers directly from KasA that average 40 carbons in length. KasA and KasB thus function in tandem to carrier out acyl chain elongation to achieve meromycolic acid synthesis from acyl primers provided by type I fatty acid synthase system | Mycobacterium tuberculosis |
| 2.3.1.294 | metabolism | when enzyme KasB is coexpressed with KasA, it appears to be capable of facilitating the production of lipids of the length of full meromycolic acids. KasB therefore may accept primers directly from KasA that average 40 carbons in length. KasA and KasB thus function in tandem to carrier out acyl chain elongation to achieve meromycolic acid synthesis from acyl primers provided by type I fatty acid synthase system | Mycobacterium tuberculosis |
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