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Literature summary extracted from

  • Vilcheze, C.; Molle, V.; Carrere-Kremer, S.; Leiba, J.; Mourey, L.; Shenai, S.; Baronian, G.; Tufariello, J.; Hartman, T.; Veyron-Churlet, R.; Trivelli, X.; Tiwari, S.; Weinrick, B.; Alland, D.; Guerardel, Y.; Jacobs Jr., W.; Kremer, L.
    Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis (2014), PLoS Pathog., 10, e1004115 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.294 expressed in Mycobacterium smegmatis Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.294 T334A phosphoablative mutant Mycobacterium tuberculosis
2.3.1.294 T334A/T336A phosphoablative mutant Mycobacterium tuberculosis
2.3.1.294 T334D/T336D the phosphomimetic mutant exhibits loss of acid-fast staining and is more susceptible to isoniazid, ethionamide and rifampicin compared to the wild type enzyme Mycobacterium tuberculosis
2.3.1.294 T336A phosphoablative mutant Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.294 Mycobacterium tuberculosis
-
-
-
2.3.1.294 Mycobacterium tuberculosis H37Rv
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.1.294 phosphoprotein phosphorylation of the enzyme at Thr334 and Thr336 profoundly decreases the condensing activity of the enzyme. Phosphorylation of the enzyme leads to increased cell wall permeability Mycobacterium tuberculosis

Subunits

EC Number Subunits Comment Organism
2.3.1.294 ? x * 50000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.3.1.294 beta-ketoacyl-acyl carrier protein synthase
-
 Mycobacterium tuberculosis
2.3.1.294 KasB
-
 Mycobacterium tuberculosis