EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.21.B61 | expression in HEK-293T cell | Homo sapiens |
3.4.21.122 | expression in HEK-293T cell | Sus scrofa |
3.4.21.122 | expression in HEK-293T cell | Homo sapiens |
3.4.21.122 | expression in HEK-293T cell | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.B61 | Homo sapiens | O60235 | - |
- |
3.4.21.122 | Homo sapiens | O15393 | - |
- |
3.4.21.122 | Mus musculus | Q9JIQ8 | - |
- |
3.4.21.122 | Sus scrofa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.B61 | epithelial cell | - |
Homo sapiens | - |
3.4.21.B61 | leukocyte | including alveolar macrophages | Homo sapiens | - |
3.4.21.B61 | additional information | bronchial and intestinal smooth muscle cells are negative for HAT staining | Homo sapiens | - |
3.4.21.B61 | myocyte | of blood vessels, no expression in cardiac myocyte | Homo sapiens | - |
3.4.21.B61 | pneumocyte | low expression level | Homo sapiens | - |
3.4.21.122 | epithelial cell | TMPRSS2 is expressed by epithelial cells at all sites examined in the aerodigestive tracts as well as by many endothelial cells | Homo sapiens | - |
3.4.21.122 | leukocyte | including alveolar macrophages | Homo sapiens | - |
3.4.21.122 | myocyte | of blood vessels | Homo sapiens | - |
3.4.21.122 | pneumocyte | - |
Homo sapiens | - |
3.4.21.122 | smooth muscle | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.B61 | hemagglutinin precursor HA0 + H2O | - |
Homo sapiens | hemagglutinin HA1 + ? | - |
? | |
3.4.21.B61 | SARS coronavirus spike protein + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.122 | hemagglutinin precursor HA0 + H2O | - |
Sus scrofa | hemagglutinin HA1 + ? | - |
? | |
3.4.21.122 | hemagglutinin precursor HA0 + H2O | - |
Homo sapiens | hemagglutinin HA1 + ? | - |
? | |
3.4.21.122 | hemagglutinin precursor HA0 + H2O | - |
Mus musculus | hemagglutinin HA1 + ? | - |
? | |
3.4.21.122 | SARS coronavirus spike protein + H2O | - |
Sus scrofa | ? | - |
? | |
3.4.21.122 | SARS coronavirus spike protein + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.122 | SARS coronavirus spike protein + H2O | - |
Mus musculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.B61 | MAT | - |
Homo sapiens |
3.4.21.B61 | TMPRSS11D | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.21.B61 | physiological function | both proteases HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract | Homo sapiens |
3.4.21.122 | physiological function | both proteases HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract. Coexpression of ACE2 and TMPRSS2 is frequently found in the upper and lower aerodigestive tract, with the exception of the vocal folds, epiglottis and trachea. Activation of influenza virus is conserved between human, avian and porcine TMPRSS2 | Sus scrofa |
3.4.21.122 | physiological function | both proteases HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract. Coexpression of ACE2 and TMPRSS2 is frequently found in the upper and lower aerodigestive tract, with the exception of the vocal folds, epiglottis and trachea. Activation of influenza virus is conserved between human, avian and porcine TMPRSS2 | Homo sapiens |