Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bertram, S.; Heurich, A.; Lavender, H.; Gierer, S.; Danisch, S.; Perin, P.; Lucas, J.M.; Nelson, P.S.; Poehlmann, S.; Soilleux, E.J.
    Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts (2012), PLoS ONE, 7, e35876 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B61 expression in HEK-293T cell Homo sapiens
3.4.21.122 expression in HEK-293T cell Sus scrofa
3.4.21.122 expression in HEK-293T cell Homo sapiens
3.4.21.122 expression in HEK-293T cell Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B61 Homo sapiens O60235
-
-
3.4.21.122 Homo sapiens O15393
-
-
3.4.21.122 Mus musculus Q9JIQ8
-
-
3.4.21.122 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B61 epithelial cell
-
Homo sapiens
-
3.4.21.B61 leukocyte including alveolar macrophages Homo sapiens
-
3.4.21.B61 additional information bronchial and intestinal smooth muscle cells are negative for HAT staining Homo sapiens
-
3.4.21.B61 myocyte of blood vessels, no expression in cardiac myocyte Homo sapiens
-
3.4.21.B61 pneumocyte low expression level Homo sapiens
-
3.4.21.122 epithelial cell TMPRSS2 is expressed by epithelial cells at all sites examined in the aerodigestive tracts as well as by many endothelial cells Homo sapiens
-
3.4.21.122 leukocyte including alveolar macrophages Homo sapiens
-
3.4.21.122 myocyte of blood vessels Homo sapiens
-
3.4.21.122 pneumocyte
-
Homo sapiens
-
3.4.21.122 smooth muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B61 hemagglutinin precursor HA0 + H2O
-
Homo sapiens hemagglutinin HA1 + ?
-
?
3.4.21.B61 SARS coronavirus spike protein + H2O
-
Homo sapiens ?
-
?
3.4.21.122 hemagglutinin precursor HA0 + H2O
-
Sus scrofa hemagglutinin HA1 + ?
-
?
3.4.21.122 hemagglutinin precursor HA0 + H2O
-
Homo sapiens hemagglutinin HA1 + ?
-
?
3.4.21.122 hemagglutinin precursor HA0 + H2O
-
Mus musculus hemagglutinin HA1 + ?
-
?
3.4.21.122 SARS coronavirus spike protein + H2O
-
Sus scrofa ?
-
?
3.4.21.122 SARS coronavirus spike protein + H2O
-
Homo sapiens ?
-
?
3.4.21.122 SARS coronavirus spike protein + H2O
-
Mus musculus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B61 MAT
-
Homo sapiens
3.4.21.B61 TMPRSS11D
-
Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.B61 physiological function both proteases HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract Homo sapiens
3.4.21.122 physiological function both proteases HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract. Coexpression of ACE2 and TMPRSS2 is frequently found in the upper and lower aerodigestive tract, with the exception of the vocal folds, epiglottis and trachea. Activation of influenza virus is conserved between human, avian and porcine TMPRSS2 Sus scrofa
3.4.21.122 physiological function both proteases HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract. Coexpression of ACE2 and TMPRSS2 is frequently found in the upper and lower aerodigestive tract, with the exception of the vocal folds, epiglottis and trachea. Activation of influenza virus is conserved between human, avian and porcine TMPRSS2 Homo sapiens