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Literature summary extracted from

  • Checler, F.; Ferro, E.S.
    Neurolysin from initial detection to latest advances (2018), Neurochem. Res., 43, 2017-2024 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.16 gene NLN Rattus norvegicus
3.4.24.16 gene NLN Mus musculus
3.4.24.16 gene NLN Homo sapiens
3.4.24.16 gene NLN Sus scrofa
3.4.24.16 gene NLN Bos taurus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.16 additional information generation of Nln knockout C57BL6 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.16 Mcc-Pro-Leu Nln-mediated hydrolysis of Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp yields a degradation product that triggers product inhibition Bos taurus
3.4.24.16 Mcc-Pro-Leu Nln-mediated hydrolysis of QFS yields a degradation product that triggers a relatively product inhibition Homo sapiens
3.4.24.16 Mcc-Pro-Leu Nln-mediated hydrolysis of Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp yields a degradation product that triggers a product inhibition Mus musculus
3.4.24.16 Mcc-Pro-Leu Nln-mediated hydrolysis of QFS yields a degradation product that triggers a relatively product inhibition Rattus norvegicus
3.4.24.16 Mcc-Pro-Leu Nln-mediated hydrolysis of Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp yields a degradation product that triggers a relatively product inhibition Sus scrofa
3.4.24.16 additional information Pro-Ile is unable to affect endopeptidases 24.11 and 24.15, proline endopeptidase, angiotensin-converting enzyme, leucine aminopeptidase, diglutamyl aminopeptidase, and trypsin Bos taurus
3.4.24.16 additional information Pro-Ile is unable to affect endopeptidases 24.11 and 24.15, proline endopeptidase, angiotensin-converting enzyme, leucine aminopeptidase, diglutamyl aminopeptidase, and trypsin Homo sapiens
3.4.24.16 additional information Pro-Ile is unable to affect endopeptidases 24.11 and 24.15, proline endopeptidase, angiotensin-converting enzyme, leucine aminopeptidase, diglutamyl aminopeptidase, and trypsin Mus musculus
3.4.24.16 additional information Pro-Ile is unable to affect endopeptidases 24.11 and 24.15, proline endopeptidase, angiotensin-converting enzyme, leucine aminopeptidase, diglutamyl aminopeptidase, and trypsin Rattus norvegicus
3.4.24.16 additional information Pro-Ile is unable to affect endopeptidases 24.11 and 24.15, proline endopeptidase, angiotensin-converting enzyme, leucine aminopeptidase, diglutamyl aminopeptidase, and trypsin Sus scrofa
3.4.24.16 Pro-Ile
-
Bos taurus
3.4.24.16 Pro-Ile
-
Homo sapiens
3.4.24.16 Pro-Ile
-
Mus musculus
3.4.24.16 Pro-Ile
-
Rattus norvegicus
3.4.24.16 Pro-Ile
-
Sus scrofa
3.4.24.16 Pro-L-PhePsi(PO2CH2)Gly-Pro
-
Bos taurus
3.4.24.16 Pro-L-PhePsi(PO2CH2)Gly-Pro
-
Homo sapiens
3.4.24.16 Pro-L-PhePsi(PO2CH2)Gly-Pro
-
Mus musculus
3.4.24.16 Pro-L-PhePsi(PO2CH2)Gly-Pro
-
Rattus norvegicus
3.4.24.16 Pro-L-PhePsi(PO2CH2)Gly-Pro
-
Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.16 membrane
-
Mus musculus 16020
-
3.4.24.16 membrane
-
Homo sapiens 16020
-
3.4.24.16 membrane
-
Sus scrofa 16020
-
3.4.24.16 membrane
-
Bos taurus 16020
-
3.4.24.16 mitochondrion
-
Rattus norvegicus 5739
-
3.4.24.16 mitochondrion
-
Mus musculus 5739
-
3.4.24.16 mitochondrion
-
Homo sapiens 5739
-
3.4.24.16 mitochondrion
-
Sus scrofa 5739
-
3.4.24.16 mitochondrion
-
Bos taurus 5739
-
3.4.24.16 plasma membrane
-
Rattus norvegicus 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.16 Zn2+ zinc metallopeptidase Rattus norvegicus
3.4.24.16 Zn2+ zinc metallopeptidase Mus musculus
3.4.24.16 Zn2+ zinc metallopeptidase Homo sapiens
3.4.24.16 Zn2+ zinc metallopeptidase Sus scrofa
3.4.24.16 Zn2+ zinc metallopeptidase Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.16 GlpLYENKPRRPYIL + H2O Homo sapiens neurotensin, secreted human neuropeptide GlpLYENKPRRP + YIL
-
?
3.4.24.16 additional information Mus musculus Nln hydrolyses several substrates that are affected by brain injury ?
-
?
3.4.24.16 additional information Mus musculus C57BL6 Nln hydrolyses several substrates that are affected by brain injury ?
-
?
3.4.24.16 neurotensin + H2O Rattus norvegicus secreted neuropeptide ?
-
?
3.4.24.16 neurotensin + H2O Mus musculus secreted neuropeptide GlpLYENKPRRP + YIL
-
?
3.4.24.16 neurotensin + H2O Sus scrofa secreted neuropeptide GlpLYENKPRRP + YIL
-
?
3.4.24.16 neurotensin + H2O Bos taurus secreted neuropeptide GlpLYENKPRRP + YIL
-
?
3.4.24.16 neurotensin + H2O Mus musculus C57BL6 secreted neuropeptide GlpLYENKPRRP + YIL
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.16 Bos taurus A2VDQ5
-
-
3.4.24.16 Homo sapiens Q9BYT8
-
-
3.4.24.16 Mus musculus Q91YP2
-
-
3.4.24.16 Mus musculus C57BL6 Q91YP2
-
-
3.4.24.16 Rattus norvegicus P42676
-
-
3.4.24.16 Sus scrofa Q02038
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.16 B16F10-Nex2 cell
-
Mus musculus
-
3.4.24.16 brain
-
Rattus norvegicus
-
3.4.24.16 brain
-
Mus musculus
-
3.4.24.16 brain
-
Homo sapiens
-
3.4.24.16 brain
-
Sus scrofa
-
3.4.24.16 brain
-
Bos taurus
-
3.4.24.16 gastric fundus
-
Rattus norvegicus
-
3.4.24.16 gastric smooth muscle
-
Rattus norvegicus
-
3.4.24.16 gastrointestinal tract
-
Rattus norvegicus
-
3.4.24.16 gastrointestinal tract
-
Mus musculus
-
3.4.24.16 gastrointestinal tract
-
Sus scrofa
-
3.4.24.16 ileum
-
Rattus norvegicus
-
3.4.24.16 intestine
-
Homo sapiens
-
3.4.24.16 intestine
-
Bos taurus
-
3.4.24.16 melanoma cell
-
Mus musculus
-
3.4.24.16 additional information membrane-bound Nln is up-regulated in mouse brain regions (frontoparietal cortex, striatum, and hippocampus) after stroke Mus musculus
-
3.4.24.16 N1E-115 cell
-
Mus musculus
-
3.4.24.16 neuron primary cultured cells Rattus norvegicus
-
3.4.24.16 neuron primary cultured cells Mus musculus
-
3.4.24.16 neuron primary cultured cells Homo sapiens
-
3.4.24.16 neuron primary cultured cells Sus scrofa
-
3.4.24.16 neuron primary cultured cells Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.16 GlpLYENKPRRPYIL + H2O neurotensin, secreted human neuropeptide Homo sapiens GlpLYENKPRRP + YIL
-
?
3.4.24.16 GlpLYENKPRRPYIL + H2O neurotensin, secreted human neuropeptide, Nln cleaves the Pro10-Tyr11 bond, but not the Arg8-Arg9 bond Homo sapiens GlpLYENKPRRP + YIL
-
?
3.4.24.16 Mcc-Pro-Leu-Gly-Pro-D-Lys(Dnp) + H2O
-
Mus musculus ?
-
?
3.4.24.16 Mcc-Pro-Leu-Gly-Pro-D-Lys(Dnp) + H2O
-
Sus scrofa ?
-
?
3.4.24.16 Mcc-Pro-Leu-Gly-Pro-D-Lys(Dnp) + H2O
-
Bos taurus ?
-
?
3.4.24.16 Mcc-Pro-Leu-Gly-Pro-D-Lys(Dnp) + H2O substrate QFS Rattus norvegicus ?
-
?
3.4.24.16 Mcc-Pro-Leu-Gly-Pro-D-Lys(Dnp) + H2O substrate QFS Homo sapiens ?
-
?
3.4.24.16 Mcc-Pro-Leu-Gly-Pro-D-Lys(Dnp) + H2O
-
Mus musculus C57BL6 ?
-
?
3.4.24.16 additional information Nln hydrolyses several substrates that are affected by brain injury Mus musculus ?
-
?
3.4.24.16 additional information Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp and neurotensin compete for their hydrolysis by enzyme Nln Sus scrofa ?
-
?
3.4.24.16 additional information Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp and neurotensin compete for their hydrolysis by enzyme Nln Bos taurus ?
-
?
3.4.24.16 additional information Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp and neurotensin compete for their hydrolysis by enzyme Nln. Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp is particularly useful to study Nln distribution and ontogeny in murine brain Mus musculus ?
-
?
3.4.24.16 additional information QFS and neurotensin compete for their hydrolysis by enzyme Nln Rattus norvegicus ?
-
?
3.4.24.16 additional information QFS and neurotensin compete for their hydrolysis by enzyme Nln Homo sapiens ?
-
?
3.4.24.16 additional information Nln hydrolyses several substrates that are affected by brain injury Mus musculus C57BL6 ?
-
?
3.4.24.16 additional information Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp and neurotensin compete for their hydrolysis by enzyme Nln. Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp is particularly useful to study Nln distribution and ontogeny in murine brain Mus musculus C57BL6 ?
-
?
3.4.24.16 neurotensin + H2O secreted neuropeptide Rattus norvegicus ?
-
?
3.4.24.16 neurotensin + H2O secreted neuropeptide, major cleavage is the Pro10-Tyr11 bond, but not the Arg8-Arg9 bond. Neurotensin in which Tyr 11 is replaced by a D-Tyr11 or D-Phe11 residue fully resists degradation both in vitro as well as in vivo, after intracerebroventricular administration in rat Rattus norvegicus ?
-
?
3.4.24.16 neurotensin + H2O secreted neuropeptide Mus musculus GlpLYENKPRRP + YIL
-
?
3.4.24.16 neurotensin + H2O secreted neuropeptide Sus scrofa GlpLYENKPRRP + YIL
-
?
3.4.24.16 neurotensin + H2O secreted neuropeptide Bos taurus GlpLYENKPRRP + YIL
-
?
3.4.24.16 neurotensin + H2O secreted neuropeptide, Nln cleaves the Pro10-Tyr11 bond, but not the Arg8-Arg9 bond Mus musculus GlpLYENKPRRP + YIL
-
?
3.4.24.16 neurotensin + H2O secreted neuropeptide, Nln cleaves the Pro10-Tyr11 bond, but not the Arg8-Arg9 bond Sus scrofa GlpLYENKPRRP + YIL
-
?
3.4.24.16 neurotensin + H2O secreted neuropeptide, Nln cleaves the Pro10-Tyr11 bond, but not the Arg8-Arg9 bond Bos taurus GlpLYENKPRRP + YIL
-
?
3.4.24.16 neurotensin + H2O secreted neuropeptide Mus musculus C57BL6 GlpLYENKPRRP + YIL
-
?
3.4.24.16 neurotensin + H2O secreted neuropeptide, Nln cleaves the Pro10-Tyr11 bond, but not the Arg8-Arg9 bond Mus musculus C57BL6 GlpLYENKPRRP + YIL
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.16 endopeptidase 3.4.24.16
-
Rattus norvegicus
3.4.24.16 endopeptidase 3.4.24.16
-
Mus musculus
3.4.24.16 endopeptidase 3.4.24.16
-
Homo sapiens
3.4.24.16 endopeptidase 3.4.24.16
-
Sus scrofa
3.4.24.16 endopeptidase 3.4.24.16
-
Bos taurus
3.4.24.16 neurotensin-cleaving enzyme
-
Rattus norvegicus
3.4.24.16 neurotensin-cleaving enzyme
-
Mus musculus
3.4.24.16 neurotensin-cleaving enzyme
-
Homo sapiens
3.4.24.16 neurotensin-cleaving enzyme
-
Sus scrofa
3.4.24.16 neurotensin-cleaving enzyme
-
Bos taurus
3.4.24.16 Nln
-
Rattus norvegicus
3.4.24.16 Nln
-
Mus musculus
3.4.24.16 Nln
-
Homo sapiens
3.4.24.16 Nln
-
Sus scrofa
3.4.24.16 Nln
-
Bos taurus

Expression

EC Number Organism Comment Expression
3.4.24.16 Mus musculus membrane-bound Nln is up-regulated in mouse brain regions (frontoparietal cortex, striatum, and hippocampus) after stroke up

General Information

EC Number General Information Comment Organism
3.4.24.16 evolution the enzyme belongs to the M3 metallopeptidase family Rattus norvegicus
3.4.24.16 evolution the enzyme belongs to the M3 metallopeptidase family Mus musculus
3.4.24.16 evolution the enzyme belongs to the M3 metallopeptidase family Homo sapiens
3.4.24.16 evolution the enzyme belongs to the M3 metallopeptidase family Sus scrofa
3.4.24.16 evolution the enzyme belongs to the M3 metallopeptidase family Bos taurus
3.4.24.16 physiological function Nln secreted from B16F10-Nex2 melanoma cells might be able control angiogenesis. Nln hydrolyses several substrates that are affected by brain injury Mus musculus