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Literature summary extracted from

  • Blanc, V.; Gil, P.; Bamas-Jacques, N.; Lorenzon, S.; Zagorec, M.; Schleuniger, J.; Bisch, D.; Blanche, F.; Debussche, L.; Crouzet, J.; Thibaut, D.
    Identification of analysis of genes from Streptomyces pristinaespiralis encoding enzymes involved in the biosynthesis of the 4-dimethylamino-L-phenylalanine precursor of pristinamycin I (1997), Mol. Microbiol., 23, 191-202 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.121 4-amino-4-deoxyprephenate + NAD+ Streptomyces pristinaespiralis
-
 3-(4-aminophenyl)pyruvate + CO2 + NADH + H+
-
 ?
1.3.1.121 4-amino-4-deoxyprephenate + NAD+ Streptomyces pristinaespiralis SP92
-
 3-(4-aminophenyl)pyruvate + CO2 + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.121 Streptomyces pristinaespiralis
-
-
-
1.3.1.121 Streptomyces pristinaespiralis SP92
-
-
-
5.4.99.67 Streptomyces pristinaespiralis P72541
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.121 4-amino-4-deoxyprephenate + NAD+
-
 Streptomyces pristinaespiralis 3-(4-aminophenyl)pyruvate + CO2 + NADH + H+
-
 ?
1.3.1.121 4-amino-4-deoxyprephenate + NAD+
-
 Streptomyces pristinaespiralis SP92 3-(4-aminophenyl)pyruvate + CO2 + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.121 papC
-
 Streptomyces pristinaespiralis
5.4.99.67 papB
-
 Streptomyces pristinaespiralis

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.121 NAD+
-
 Streptomyces pristinaespiralis

General Information

EC Number General Information Comment Organism
5.4.99.67 physiological function genes papA, papB, papC, papM are involved in the biosynthesis of the pristinamycin I precursor 4-dimethylamino-L-phenylalanine. PapB is a mutase responsible for the synthesis of 4-amino 4-deoxy prephenic acid Streptomyces pristinaespiralis