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Literature summary extracted from
- Meprin and ADAM metalloproteases two sides of the same coin? (2015), Matrix Metalloproteinase Biology (ed. Sagi I. and Gaffney J.P.), 2015, 115-130 .
No PubMed abstract available
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.63 | membrane | - |
Homo sapiens | 16020 | - |
| 3.4.24.63 | additional information | meprin beta does not contain an additional inserted domain (I-domain) | Homo sapiens | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.63 | Zn2+ | zinc-dependent metalloendoprotease | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.63 | angiotensin II + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.63 | bradykinin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.63 | Collagen IV + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.63 | Fibronectin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.63 | gastrin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.63 | laminin V + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.63 | nidogen 1 + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.63 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.24.63 | proteolytic modification | activation of meprin beta by proteolytic cleavage. Meprin beta contains a conserved sequence motif, which gives rise to enzymatic activation by tryptic serine proteases. Pancreatic trypsin performs this activation in the gut. Meprin beta cannot be activated by plasmin in the gut. In skin, the human tissue kallikrein-related peptidase 4 (KLK4), KLK5, and KLK8, cleave off the propeptide of meprin beta | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.63 | angiotensin II + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.63 | bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.63 | Collagen IV + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.63 | Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.63 | gastrin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.63 | laminin V + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.63 | nidogen 1 + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.24.63 | dimer | the mature protease forms dimers which are stabilized by an intermolecular disulfide bond between the MAM domains | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.63 | meprin beta | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.24.63 | evolution | meprin beta belongs to the astacin family of zinc-endopeptidases and the metzincin superfamily, characterized by the conserved motif HExxHxxGxxHxxxRxDR. Meprin beta is the only membrane-bound member of the astacin family | Homo sapiens |
| 3.4.24.63 | physiological function | meprin beta acts at the cell surface as a sheddase, cleaving transmembrane proteins, such as the amyloid precursor protein (APP). Meprins cleave compounds of the extracellular matrix such as laminin-V, collagen IV, fibronectin or nidogen 1, but also growth factors, cytokines and peptide hormones, including bradykinin, angiotensins, and gastrin | Homo sapiens |
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Release 2023.1 (January 2023)
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